Description of position
We are looking to recruit a postdoctoral fellow to join the laboratory of Dr. Joyce Rauch at the Research Institute of the McGill University Health Centre, a research institute affiliated with the McGill University. The CIHR-funded research project will involve the investigation of programmed cell death in systemic lupus erythematosus (SLE), with a focus on delineating the mechanistic pathways responsible for the initiation of SLE and generation of multiple autoantibodies in this disease.
Dr. Rauch’s laboratory has developed a murine model of SLE in which immunization with β2-glycoprotein I (an apoptotic cell-binding protein) and lipopolysaccharide (an innate immune stimulus) leads to the emergence of SLE autoantibodies in a sequential manner similar to that seen in human SLE. The T cell response to the inducing antigen, β2-glycoprotein I, is closely associated with the production of SLE autoantibodies by B cells. Dr. Rauch’s model provides an ideal means of evaluating new therapeutics targeting the B or T cell response in SLE. It is also an excellent model for evaluating drugs that target the innate immune response and other factors affecting antigen presentation.
Dr. Rauch’s laboratory is located in the Centre for Translational Biology (CTB) of the Research Institute of the MUHC (http://rimuhc.ca/-/joyce-rauch-phd), a state-of-the-art facility opened in 2015 that provides access to multiple advanced technical platform facilities and an excellent animal facility. The CTB is adjacent to the hospital, providing ready access to patient clinics. Dr. Rauch’s laboratory is a member of the Infectious Diseases and Immunity in Global Health Program, as well as the Centre of Excellence in Translational Immunology, which are both collaborative, multidisciplinary research groups.
The postdoctoral fellowship position is for a period of three years. Dr. Rauch will provide salary for the first year, but will encourage and support applications for internal and external fellowship funding for subsequent years.
Qualifications / Required skills
The applicant should have a Ph.D. degree (obtained within the past 1-3 years), and a strong background in immunology and molecular biology. The applicant should also have expertise in flow cytometry, cellular assays, Western blot analysis, molecular biological methods (e.g., PCR), and murine models of disease. Salary will be negotiated dependent on experience.
Province: Montreal, Quebec
Position: Post-doctoral fellowship
Posted: March 2019