Lab Information

Dr. Matthew Cheng

Junior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 60%
 Epidemiology: 0%
 Evaluation: 0%
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Lethal infectious diseases • opportunistic infections • sepsis • bacteremia

Research Interests

My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.

Team Members

Name Position

Latest Publications

  1. Boodman, C. & Cheng, M. P. (2021). Nosocomial mucormycosis of the thigh. IDCases, vol. 25, p. e01225.
  2. Bobrovitz, N., Arora, R. K., Cao, C., Boucher, E., Liu, M., Donnici, C., Yanes-Lane, M., Whelan, M., Perlman-Arrow, S., Chen, J., Rahim, H., Ilincic, N., Segal, M., Duarte, N., Van Wyk, J., Yan, T., Atmaja, A., Rocco, S., Joseph, A., Penny, L., Clifton, D. A., Williamson, T., Yansouni, C. P., Evans, T. G., Chevrier, J., Papenburg, J. & Cheng, M. P. (2021). Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis. PloS one, vol. 16, p. e0252617.
  3. Papenburg, J., Cheng, M. P., Corsini, R., Caya, C., Mendoza, E., Manguiat, K., Lindsay, L. R., Wood, H., Drebot, M. A., Dibernardo, A., Zaharatos, G., Bazin, R., Gasser, R., Benlarbi, M., Gendron-Lepage, G., Beaudoin-Bussières, G., Prévost, J., Finzi, A., Ndao, M. & Yansouni, C. P. (2021). Evaluation of a Commercial Culture-Free Neutralization Antibody Detection Kit for Severe Acute Respiratory Syndrome-Related Coronavirus-2 and Comparison With an Antireceptor-Binding Domain Enzyme-Linked Immunosorbent Assay. Open forum infectious diseases, vol. 8, p. ofab220.
  4. Vinh, D. C., Abel, L., Bastard, P., Cheng, M. P., Condino-Neto, A., Gregersen, P. K., Haerynck, F., Cicalese, M.-P., Hagin, D., Soler-Palacín, P., Planas, A. M., Pujol, A., Notarangelo, L. D., Zhang, Q., Su, H. C., Casanova, J.-L., Meyts, I. & COVID Human Genetic Effort (2021). Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β. Journal of clinical immunology.
  5. Koo, S., Bold, T. D., Cheng, M. P., Farmakiotis, D., Hill, J. A., Knoll, B., Koullias, Y., Letourneau, A. R., Little, J., Moulton, E. A., Weiss, Z. F. & Hammond, S. P. (2021). A eulogy for Dr Francisco Miguel Marty Forero. Transplant infectious disease : an official journal of the Transplantation Society, p. e13645.
  6. Ward, B. J., Gobeil, P., Séguin, A., Atkins, J., Boulay, I., Charbonneau, P.-Y., Couture, M., D'Aoust, M.-A., Dhaliwall, J., Finkle, C., Hager, K., Mahmood, A., Makarkov, A., Cheng, M. P., Pillet, S., Schimke, P., St-Martin, S., Trépanier, S. & Landry, N. (2021). Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19. Nature medicine, vol. 27, p. 1071-1078.
  7. Akhter, M. & Cheng, M. P. (2021). Optimizing cost as well as yield of blood cultures in sepsis. The American journal of emergency medicine.
  8. Demir, K. K., Butler-Laporte, G., Del Corpo, O., Ekmekjian, T., Sheppard, D. C., Lee, T. C. & Cheng, M. P. (2021). Comparative effectiveness of amphotericin B, azoles and echinocandins in the treatment of candidemia and invasive candidiasis: A systematic review and network meta-analysis. Mycoses.
  9. Cheng, M. P., Cau, A., Lee, T. C., Brodie, D., Slutsky, A., Marshall, J., Murthy, S., Lee, T., Singer, J., Demir, K. K., Boyd, J., Ohm, H., Maslove, D., Goffi, A., Bogoch, I. I., Sweet, D. D., Walley, K. R., Russell, J. A. & Angiotensin Receptor Blocker Coronavirus Study (ARBs) CORONA I (2021). Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections-A Systematic Review and Meta-Analysis. Critical care medicine.
  10. Lee, T., Cau, A., Cheng, M. P., Levin, A., Lee, T. C., Vinh, D. C., Lamontagne, F., Singer, J., Walley, K. R., Murthy, S., Patrick, D., Rewa, O. G., Winston, B. W., Marshall, J., Boyd, J., Tran, K., Kalil, A., McCuloh, R., Fowler, R., Luther, J. M., Russell, J. A. & ARBs CORONA (2021). ANGIOTENSIN RECEPTOR BLOCKERS AND ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN COVID-19 -META-ANALYSIS/META-REGRESSION ADJUSTED FOR CONFOUNDING FACTORS. CJC open.
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