Lab Information

Dr. Martin Olivier

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 EM3.3220
 E03.3150 (modules M, N, O, P) /  #76291

Keywords

Leishmaniasis • malaria • exosome • innate inflammation • signaling

Research Interests

My research focuses on understanding how pathogens can evade the host immune response by manipulating the biochemical cascades involved in the regulation of phagocyte microbicidal functions. My pathogens of interest are protozoan parasites causing malaria, which causes up to two millions deaths annually, and leishmaniasis, which affects more than 250 million individuals worldwide. I have found that leishmania can tame the innate inflammatory response of the host, using its surface protease that can also be contained in microvesicules rapidly released within the host environment. For Malaria, my research revealed that a crystalline metabolic waste (HZ) of the parasite was responsible for a great number of inflammation-related pathologies encountered during this important infection. My lab's findings may lead to the development of new therapies against those infectious agents, which could be applied to others such as tuberculosis. They might also lead to the development of new diagnostic tools based on exo-biomarkers, and potentially to vaccine development.


Team Members

Name Position
Lira Filho, Alonso PhD Student
Dong, George PhD Student
Al-Emadi, Nada MSc Student
Larivière, Line Research Assistant
Villalba Guerrero, Carlos PhD Student
Brouillard-Galipeau, Morgane Undergraduate
Dagenais, Amy MSc Student
Lafleur, Andrea MSc Student
Sgro, Sabrina Undergraduate

Latest Publications

  1. Heirwegh, E., MacLean, E., He, J., Kamhawi, S., Sagan, S. M. & Olivier, M. (2021). Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation. PLoS neglected tropical diseases, vol. 15, p. e0009638.
  2. Nguyen, A. M. T., Brettell, S., Douanne, N., Duquette, C., Corbeil, A., Fajardo, E. F., Olivier, M., Fernandez-Prada, C. & Lubell, W. D. (2021). Influence of N-Methylation and Conformation on Almiramide Anti-Leishmanial Activity. Molecules (Basel, Switzerland), vol. 26.
  3. Dong, G., Wagner, V., Minguez-Menendez, A., Fernandez-Prada, C. & Olivier, M. (2021). Extracellular vesicles and leishmaniasis: Current knowledge and promising avenues for future development. Molecular immunology, vol. 135, p. 73-83.
  4. Torrecilhas, A. C., Soares, R. P., Schenkman, S., Fernández-Prada, C. & Olivier, M. (2020). Extracellular Vesicles in Trypanosomatids: Host Cell Communication. Frontiers in cellular and infection microbiology, vol. 10, p. 602502.
  5. Vialard, F. & Olivier, M. (2020). Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?. Frontiers in immunology, vol. 11, p. 588387.
  6. Olivier, M. & Zamboni, D. S. (2020). Leishmania Viannia guyanensis, LRV1 virus and extracellular vesicles: a dangerous trio influencing the faith of immune response during muco-cutaneous leishmaniasis. Current opinion in immunology, vol. 66, p. 108-113.
  7. Douanne, N., Dong, G., Douanne, M., Olivier, M. & Fernandez-Prada, C. (2020). Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites. PLoS neglected tropical diseases, vol. 14, p. e0008439.
  8. Vucetic, A., Filho, A. D. S. L., Dong, G. & Olivier, M. (2020). Isolation of Extracellular Vesicles from Leishmania spp. Methods in molecular biology (Clifton, N.J.), vol. 2116, p. 555-574.
  9. Carvalho Cabral, P., Olivier, M. & Cermakian, N. (2019). The Complex Interplay of Parasites, Their Hosts, and Circadian Clocks. Frontiers in cellular and infection microbiology, vol. 9, p. 425.
  10. Alriyami, M., Marchand, L., Li, Q., Du, X., Olivier, M. & Polychronakos, C. (2019). Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice. Genome research, vol. 29, p. 1951-1961.
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