Lab Information

Dr. Marina Klein

Senior Scientist
Centre for Outcomes Research and Evaluation
Department of Medicine (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 20%
 Epidemiology: 80%
 Evaluation: 0%
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HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohort

Research Interests

My research focuses on the treatment of patients with HIV and chronic hepatitis. As a prominent researcher in clinical and epidemiologic aspects of HIV and Hepatitis C co-infection, I lead one the largest multicenter cohorts focused on HIV/HCV co-infection in the world, recruiting more than one thousand HIV/HCV co-infected patients across Canada. The primary objectives of the CIHR funded cohort are to study the interactions between these two chronic viruses and their natural history in the era of combination antiretroviral therapy (cART) and to evaluate therapeutic strategies aimed at improving health outcomes in co-infected persons. We are also focused on understanding the roles of co-morbidities in the natural history of HIV/HCV co-infection. In addition, I am involved in a number of observational epidemiologic research collaborations (NA-ACCORD and CANOC) that focus on understanding long term clinical and treatment outcomes in HIV infection. My other research interests include antiretroviral pharmacoepidemiology and HIV infection in women.

Team Members

Name Position
Espaldon, Reynan Research Coordinator
Espaldon, Eshel Laboratory Technician
Pineda, Rhyan Research Coordinator
Lanièce, Charlotte PhD Student
Marathe, Gayatri Jayant PhD Student
Burelle, Chantal Administrative Assistant
Lumia, Jessica Health Records Technician
Pexos, Costa Data Analyst
Peiris, Hansi Project Manager
Paisible, Nathalie Research Nurse
Del Balso, Lina Research Nurse
Thériault, Guillaume Research Nurse
Djurabekova, Nigina Clinical Coordinator
Lavazos, Vicky Ethics and Regulatory Coordinator
Fraraccio, Maria Clinical Coordinator
Robichaud, Isabelle Clinical Coordinator
Wang, Shouao Biostatistician
Ortiz-Paredes, David Felipe Research Assistant
Muntini, Naiana Research Coordinator
Milbers, Katherine Junior Assistant
Proulx-Boucher, Karene Ethics and Regulatory Coordinator
DelBaso, Lina Research Nurse

Latest Publications

  1. Zhabokritsky, A., Szadkowski, L., Burchell, A. N., Cooper, C., Hogg, R. S., Hull, M., Kelly, D. V., Klein, M., Loutfy, M., McClean, A., Montaner, J., Walmsley, S. L. & Canadian Observational Cohort (CANOC) Collaboration (2021). Immunological and virological response to initial antiretroviral therapy among older people living with HIV in the Canadian Observational Cohort (CANOC). HIV medicine.
  2. McClean, A. R., Kooij, K. W., Trigg, J., Ye, M., Sereda, P., McLinden, T., Bacani, N., Aran, N., Thomas, R., Wong, A., Klein, M. B., Hull, M., Cooper, C., Salters, K., Hogg, R. S. & CANOC Collaboration (2021). Tobacco smoking and HIV-related immunologic and virologic response among individuals of the Canadian HIV Observational Cohort (CANOC). AIDS care, p. 1-10.
  3. Park, H., Brenner, B., Ibanescu, R.-I., Cox, J., Weiss, K., Klein, M. B., Hardy, I., Narasiah, L., Roger, M. & Kronfli, N. (2021). Phylogenetic Clustering among Asylum Seekers with New HIV-1 Diagnoses in Montreal, QC, Canada. Viruses, vol. 13.
  4. Palayew, A., Schmidt, A. M., Saeed, S., Cooper, C. L., Wong, A., Martel-Laferrière, V., Walmsley, S., Cox, J., Klein, M. B. & Canadian Coinfection Cohort Study Investigators (2021). Estimating an individual-level deprivation index for HIV/HCV coinfected persons in Canada. PloS one, vol. 16, p. e0249836.
  5. Amoako, A., Ortiz-Paredes, D., Engler, K., Lebouché, B., Klein, M. B., Amoako, A., Ortiz-Paredes, D., Engler, K., Lebouché, B. & Klein, M. B. (2021). Patient and provider perceived barriers and facilitators to direct acting antiviral hepatitis C treatment among priority populations in high income countries: A knowledge synthesis. The International journal on drug policy, p. 103247.
  6. Nina Kim, H., Newcomb, C. W., Carbonari, D. M., Roy, J. A., Torgersen, J., Althoff, K. N., Kitahata, M. M., Rajender Reddy, K., Lim, J. K., Silverberg, M. J., Mayor, A. M., Horberg, M. A., Cachay, E. R., Kirk, G. D., Sun, J., Hull, M., John Gill, M., Sterling, T. R., Kostman, J. R., Peters, M. G., Moore, R. D., Klein, M. B., Lo Re, V., The North American Aids Cohort Collaboration On Research, F. & Of IeDEA, D. (2021). Risk of Hepatocellular Carcinoma with Hepatitis B Viremia among HIV/Hepatitis B Virus-Coinfected Persons in North America. Hepatology (Baltimore, Md.).
  7. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2021). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, p. 1-7.
  8. Sun, J., Althoff, K. N., Jing, Y., Horberg, M. A., Buchacz, K., Gill, M. J., Justice, A. C., Rabkin, C. S., Goedert, J. J., Sigel, K., Cachay, E., Park, L., Lim, J. K., Kim, H. N., Lo Re, V., Moore, R., Sterling, T., Peters, M. G., Achenbach, C. J., Silverberg, M., Thorne, J. E., Mayor, A. M., Crane, H. M., Kitahata, M. M., Klein, M., Kirk, G. D. & North American AIDS Cohort Collaboration on Research and Design of IeDEA (2021). Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015. JAMA network open, vol. 4, p. e2037512.
  9. Davy-Mendez, T., Napravnik, S., Eron, J. J., Cole, S. R., van Duin, D., Wohl, D. A., Hogan, B. C., Althoff, K. N., Gebo, K. A., Moore, R. D., Silverberg, M. J., Horberg, M. A., Gill, M. J., Mathews, W. C., Klein, M. B., Colasanti, J. A., Sterling, T. R., Mayor, A. M., Rebeiro, P. F., Buchacz, K., Li, J., Nanditha, N. G. A., Thorne, J. E., Nijhawan, A., Berry, S. A. & North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA (2020). Current and Past Immunodeficiency are Associated with Higher Hospitalization Rates among Persons on Virologically Suppressive Antiretroviral Therapy for up to Eleven Years. The Journal of infectious diseases.
  10. Sangaré, M. N., Baril, J.-G., de Pokomandy, A., Laprise, C., Deshaies, C., Klein, M., Thomas, R., Tremblay, C., Roger, M., Pexos, C., Greenwald, Z., Machouf, N., Durand, M., Hardy, I., Dakouo, M., Laporte, L. & Trottier, H. (2020). Impact of previous HIV resistance and virologic failures on virologic outcome following a switch to dolutegravir with 2 NRTIs among people living with HIV. Medicine, vol. 99, p. e23335.
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