Lab Information

Dr. Marie-Josée Brouillette

Centre for Outcomes Research and Evaluation
Department of Psychiatry (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 50%
 Epidemiology: 50%
 Evaluation: 0%
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Cognition in HIV • depression • rasch analysis

Research Interests

My research focuses on the psychiatric care of patients infected with HIV and those undergoing treatment for hepatitis C. These studies are concerned with regulation of cognition and mood. My main study in the area of HIV involves characterizing 900 HIV+ individuals across Canada who will be followed for 2.5 years to elucidate factors that contribute to the development of cognitive decline, with interventional trials being conducted in selected subgroups of individuals. Other projects include (1) documenting changes in cognition in HIV+ individuals at risk of cognitive decline over 1 year; (2) improving cognition in HIV+ individuals through a personalized change in antiretroviral medication informed by analysis of cerebrospinal fluid; and (3) developing a computerized tool that can measure cognitive ability in a clinical setting. All these studies involve interdisciplinary collaborations (neurology, neuropsychology, epidemiology, HIV clinicians and community groups) and aim to develop innovative solutions that can be applied in the clinic.

Team Members

Name Position
Gonzales, Fernando Research Assistant
Allard, Audrey Research Coordinator
Caceres, Katia Research Assistant

Latest Publications

  1. Mayo, N. E., Brouillette, M.-J., Nadeau, L., Dendukuri, N., Harris, M., Smaill, F., Smith, G., Thomas, R., Fellows, L. K. & Investigators from the Positive Brain Health Now Study (2021). A longitudinal view of successful aging with HIV: role of resilience and environmental factors. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation.
  2. Quigley, A., Brouillette, M.-J., Fellows, L. K. & Mayo, N. (2021). Action for better brain health among people living with HIV: protocol for a randomized controlled trial. BMC infectious diseases, vol. 21, p. 843.
  3. Milan, R., LeLorier, J., Brouillette, M.-J., Holbrook, A., Litvinov, I. V. & Rahme, E. (2021). Sex differences in factors associated with switch between systemic agents among individuals with psoriasis: A retrospective cohort study in Quebec, Canada. JAAD international, vol. 4, p. 79-83.
  4. Fernandez Cruz, A. L., Chen, C.-M., Sanford, R., Collins, D. L., Brouillette, M.-J., Mayo, N. E. & Fellows, L. K. (2021). Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men. PloS one, vol. 16, p. e0243670.
  5. Kaur, N., Fellows, L. K., Brouillette, M.-J. & Mayo, N. (2021). Development and Validation of a Cognitive Reserve Index in HIV. Journal of the International Neuropsychological Society : JINS, p. 1-9.
  6. Brouillette, M.-J., Koski, L., Forcellino, L., Gasparri, J., Brew, B. J., Fellows, L. K., Mayo, N. E. & Cysique, L. A. (2021). Predicting occupational outcomes from neuropsychological test performance in older people with HIV. AIDS (London, England), vol. 35, p. 1765-1774.
  7. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2021). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, p. 1-7.
  8. Lebouché, B., Yero, A., Shi, T., Farnos, O., Singer, J., Kema, I., Costiniuk, C. T., Thomas, R., Brouillette, M.-J., Engler, K., Routy, J.-P., Jenabian, M.-A. & CTN PT006 Study Group (2020). Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy. HIV research & clinical practice, vol. 21, p. 182-190.
  9. Kaur, N., Aubertin-Leheudre, M., Fellows, L. K., Brouillette, M.-J. & Mayo, N. (2021). Feasibility and potential benefits of a structured exercise program on cognitive performance in HIV. AIDS care, p. 1-9.
  10. Askari, S., Fellows, L. K., Brouillette, M.-J. & Mayo, N. E. (2021). Development and validation of a voice-of-the-patient measure of cognitive concerns experienced by people living with HIV. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, vol. 30, p. 921-930.
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