Lab Information

Dr. Makeda Semret

Investigator
Centre for Innovative Medicine
Department of Medicine (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 100%
 Epidemiology: 0%
 Evaluation: 0%
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 E05.1616

Keywords

Hospital infections • infection control • molecular diagnostics • antimicrobial resistance

Research Interests

My research focuses on hospital-associated infections (HAI) in Africa and in Canada, with an emphasis on specific infection control measures that will improve quality of care and patient safety. HAI and antimicrobial resistance are a major cause of morbidity and mortality among hospitalized patients in industrialized countries. The burden of HAI and of antimicrobial resistance is largely unknown in Africa, where systematic surveillance is limited by weak laboratory infrastructure. We are systematically analyzing the characteristics of HAI in a large referral hospital in Ethiopia, in conjunction with training in infectious diseases and support of the microbiology laboratory. Additionally we are assessing the impact of laboratory diagnostics and of antimicrobial stewardship interventions on patient outcomes, antimicrobial prescriptions and antimicrobial resistance patterns in Ethiopia and in Canada.


Team Members

Name Position

Latest Publications

  1. Andrew, M. K., MacDonald, S., Godin, J., McElhaney, J. E., LeBlanc, J., Hatchette, T. F., Bowie, W., Katz, K., McGeer, A., Semret, M. & McNeil, S. A. (2021). Persistent Functional Decline Following Hospitalization with Influenza or Acute Respiratory Illness. Journal of the American Geriatrics Society, vol. 69, p. 696-703.
  2. Yansouni, C. P., Seifu, D., Libman, M., Alemayehu, T., Gizaw, S., Johansen, Ø. H., Abebe, W., Amogne, W. & Semret, M. (2020). A Feasible Laboratory-Strengthening Intervention Yielding a Sustainable Clinical Bacteriology Sector to Support Antimicrobial Stewardship in a Large Referral Hospital in Ethiopia. Frontiers in public health, vol. 8, p. 258.
  3. Cheng, M. P., Yansouni, C. P., Basta, N. E., Desjardins, M., Kanjilal, S., Paquette, K., Caya, C., Semret, M., Quach, C., Libman, M., Mazzola, L., Sacks, J. A., Dittrich, S. & Papenburg, J. (2020). Serodiagnostics for Severe Acute Respiratory Syndrome-Related Coronavirus 2 : A Narrative Review. Annals of internal medicine, vol. 173, p. 450-460.
  4. Gebretekle, G. B., Haile Mariam, D., Abebe Taye, W., Mulu Fentie, A., Amogne Degu, W., Alemayehu, T., Beyene, T., Libman, M., Gedif Fenta, T., Yansouni, C. P. & Semret, M. (2020). Half of Prescribed Antibiotics Are Not Needed: A Pharmacist-Led Antimicrobial Stewardship Intervention and Clinical Outcomes in a Referral Hospital in Ethiopia. Frontiers in public health, vol. 8, p. 109.
  5. LeBlanc, J., ElSherif, M., Ye, L., MacKinnon-Cameron, D., Ambrose, A., Hatchette, T. F., Lang, A. L., Gillis, H. D., Martin, I., Demczuk, W. H., LaFerriere, C., Andrew, M. K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A., McGeer, A., Semret, M., Trottier, S., Valiquette, L., Webster, D. & McNeil, S. A. (2020). Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015. BMJ open respiratory research, vol. 7.
  6. Lees, C., Godin, J., McElhaney, J. E., McNeil, S. A., Loeb, M., Hatchette, T. F., LeBlanc, J., Bowie, W., Boivin, G., McGeer, A., Poirier, A., Powis, J., Semret, M., Webster, D. & Andrew, M. K. (2020). Frailty Hinders Recovery From Influenza and Acute Respiratory Illness in Older Adults. The Journal of infectious diseases, vol. 222, p. 428-437.
  7. Jacobs, J., Hardy, L., Semret, M., Lunguya, O., Phe, T., Affolabi, D., Yansouni, C. & Vandenberg, O. (2019). Diagnostic Bacteriology in District Hospitals in Sub-Saharan Africa: At the Forefront of the Containment of Antimicrobial Resistance. Frontiers in medicine, vol. 6, p. 205.
  8. LeBlanc, J. J., ElSherif, M., Ye, L., MacKinnon-Cameron, D., Ambrose, A., Hatchette, T. F., Lang, A. L. S., Gillis, H. D., Martin, I., Demczuk, W., Andrew, M. K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A. E., McGeer, A., Semret, M., Trottier, S., Valiquette, L., Webster, D. & McNeil, S. A. (2019). Streptococcus pneumoniae serotype 3 is masking PCV13-mediated herd immunity in Canadian adults hospitalized with community acquired pneumonia: A study from the Serious Outcomes Surveillance (SOS) Network of the Canadian immunization research Network (CIRN). Vaccine, vol. 37, p. 5466-5473.
  9. LeBlanc, J. J., ElSherif, M., Mulpuru, S., Warhuus, M., Ambrose, A., Andrew, M., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., Green, K., Halperin, S. A., Hatchette, T. F., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J. M., Lagacé-Wiens, P., Loeb, M., Lund, A., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J. E., McGeer, A., Poirier, A., Powis, J., Richardson, D., Semret, M., Shinde, V., Smyth, D., Trottier, S., Valiquette, L., Webster, D., Ye, L. & McNeil, S. A. (2020). Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults. Journal of medical microbiology, vol. 69, p. 256-264.
  10. Semret, M. & Haraoui, L.-P. (2019). Antimicrobial Resistance in the Tropics. Infectious disease clinics of North America, vol. 33, p. 231-245.
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See also

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Cédric
Yansouni


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Michael
Libman


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Vivian
Loo


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Momar
Ndao


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Nandini
Dendukuri


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Jesse
Papenburg


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