Lab Information

Dr. Joyce Rauch

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 EM2.3244
 E03.5135 (modules I, J)
 E03.5143 (modules K, L) /  #44585

Keywords

Autoimmunity • systemic lupus erythematosus • autoantibodies • T cells • cell death

Research Interests

My research focuses on systemic lupus erythematosus (SLE), which is an autoimmune disease affecting approximately one in every 1000 Canadian women, and often causing chronic pain and premature death. Individuals with SLE develop an immune response against their own cells, but it is unclear why this response develops. We hypothesize that cells in SLE-prone individuals die in a manner that causes them to appear foreign, thus resulting in an immune response to these cells. We will use an induced model of SLE to determine whether injecting cells that have died in different ways can produce SLE autoantibodies in mice. We will also evaluate whether inhibiting different types of cell death in mice that develop SLE-like disease spontaneously can prevent autoantibody production and disease. Our research will identify the role of different forms of cell death in the development of SLE, and how modifying cell death may produce or prevent SLE.


Team Members

Name Position
Pilon, Céleste PhD Student
Lonina, Elena Laboratory Technician

Latest Publications

  1. Melki, I., Allaeys, I., Tessandier, N., Mailhot, B., Cloutier, N., Campbell, R. A., Rowley, J. W., Salem, D., Zufferey, A., Laroche, A., Lévesque, T., Patey, N., Rauch, J., Lood, C., Droit, A., McKenzie, S. E., Machlus, K. R., Rondina, M. T., Lacroix, S., Fortin, P. R. & Boilard, E. (2020). FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood, vol. 136, p. 2933-2945.
  2. Melki, I., Allaeys, I., Tessandier, N., Mailhot, B., Cloutier, N., Campbell, R. A., Rowley, J. W., Salem, D., Zufferey, A., Laroche, A., Lévesque, T., Patey, N., Rauch, J., Lood, C., Droit, A., McKenzie, S. E., Machlus, K. R., Rondina, M. T., Lacroix, S., Fortin, P. & Boilard, E. (2020). FcγRIIA expression aggravates nephritis and increases platelet activation in systemic lupus erythematosus in mice. Blood, vol. 27.
  3. Salem, D., Subang, R., Pernet, E., Divangahi, M., Pineau, C., Cayrol, R., Levine, J. S. & Rauch, J. (2019). Necroptotic cell binding of β2 -glycoprotein I provides a potential autoantigenic stimulus in systemic lupus erythematosus. Immunology and cell biology, vol. 97, p. 799-814.
  4. Becker, Y., Marcoux, G., Allaeys, I., Julien, A.-S., Loignon, R.-C., Benk-Fortin, H., Rollet-Labelle, E., Rauch, J., Fortin, P. R. & Boilard, E. (2019). Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA. Frontiers in immunology, vol. 10, p. 1026.
  5. Becker, Y., Loignon, R.-C., Julien, A.-S., Marcoux, G., Allaeys, I., Lévesque, T., Rollet-Labelle, E., Benk-Fortin, H., Cloutier, N., Melki, I., Eder, L., Wagner, É., Pelletier, M., Hajj, H. E., Tremblay, M.-È., Belleannée, C., Hébert, M.-J., Dieudé, M., Rauch, J., Fortin, P. R. & Boilard, E. (2019). Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations. Scientific reports, vol. 9, p. 4530.
  6. Rauch, J., Salem, D., Subang, R., Kuwana, M. & Levine, J. S. (2018). β2-Glycoprotein I-Reactive T Cells in Autoimmune Disease. Frontiers in immunology, vol. 9, p. 2836.
  7. Feng, L., Vujicic, S., Dietrich, M. E., Litbarg, N., Setty, S., Antoni, A., Rauch, J. & Levine, J. S. (2018). Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. The Journal of biological chemistry, vol. 293, p. 10245-10263.
  8. Salem, D., Subang, R., Kuwana, M., Levine, J. S. & Rauch, J. (2019). T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein I. Cellular & molecular immunology, vol. 16, p. 685-693.
  9. Vujicic, S., Feng, L., Antoni, A., Rauch, J. & Levine, J. S. (2016). Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death. Journal of visualized experiments : JoVE.
  10. Laplante, P., Fuentes, R., Salem, D., Subang, R., Gillis, M.-A., Hachem, A., Farhat, N., Qureshi, S. T., Fletcher, C. A., Roubey, R. A., Merhi, Y., Thorin, É., Levine, J. S., Mackman, N. & Rauch, J. (2016). Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4. Lupus, vol. 25, p. 162-76.
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Christian
Pineau


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