Lab Information

Dr. Jean-Pierre Routy

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 50%
 Clinical: 50%
 Epidemiology: 0%
 Evaluation: 0%
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 E03.5157 (modules S, T, U, V) /  #76487, #32600, #32625
 E03.5367 (modules A, B) /  #32307


HIV • vaccine • lymphoma • T cells • cytokines

Research Interests

My research focuses on HIV pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and in immune privileged sites (central nervous system, testis) will be key to develop strategy to conquer cancers and auto-immune diseases.

Team Members

Name Position
Massicotte, Angie Research Coordinator
Isnard, Stephane Postdoc
Espaldon, Reynan Research Coordinator
Espaldon, Eshel Laboratory Technician
Pineda, Rhyan Research Coordinator
Girouard, Josée Research Nurse
Fombuena, Brandon Laboratory Technician
LIn, John Laboratory Technician
Ouyang, Jing Visiting Professor
Lovi, Cezar Research Coordinator
Peng, Xiaorong Visiting Scholar

Latest Publications

  1. Bunet, R., Nayrac, M., Ramani, H., Sylla, M., Durand, M., Chartrand-Lefebvre, C., Routy, J.-P., Landay, A. L., Gauchat, J.-F., Chomont, N., Ancuta, P., Kaufmann, D. E., Bernard, N., Tremblay, C. L. & El-Far, M. (2021). Loss of CD96 Expression as a Marker of HIV-Specific CD8+ T-Cell Differentiation and Dysfunction. Frontiers in immunology, vol. 12, p. 673061.
  2. Gabriel, E. M., Salinas, T. R. W., Gosselin, A., Larouche-Anctil, E., Durand, M., Landay, A. L., El-Far, M., Tremblay, C. L., Routy, J.-P. & Ancuta, P. (2021). Overt IL-32 Isoform Expression at Intestinal Level during HIV-1 Infection is Negatively Regulated by IL-17A. AIDS (London, England).
  3. Alsulami, K., Bolastig, N., Dupuy, F. P., Mabanga, T., Gilbert, L., Kiani, Z., Routy, J.-P., Bruneau, J., Thomas, R., Tremblay, C., Tsoukas, C. M., Szabo, J., Côté, P., Trottier, B., LeBlanc, R., Rouleau, D., Bernard, N. F. & investigators in Montreal Primary HIV Infection cohort (2021). Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point. Journal of virology, p. JVI0041721.
  4. Cattin, A., Wacleche, V. S., Fonseca Do Rosario, N., Marchand, L. R., Dias, J., Gosselin, A., Cohen, E. A., Estaquier, J., Chomont, N., Routy, J.-P. & Ancuta, P. (2021). RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16+ Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4+ T Cells. Journal of immunology (Baltimore, Md. : 1950), vol. 206, p. 2638-2651.
  5. Bazié, W. W., Boucher, J., Vitry, J., Goyer, B., Routy, J. P., Tremblay, C., Trottier, S., Jenabian, M.-A., Provost, P., Alary, M. & Gilbert, C. (2021). Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIV. Pathogens & immunity, vol. 6, p. 1-28.
  6. Royston, L., Isnard, S., Calmy, A. & Routy, J.-P. (2021). Kaposi sarcoma in ART-treated people living with HIV: A wake-up call for research on HHV-8. AIDS (London, England).
  7. El-Far, M., Durand, M., Turcotte, I., Larouche-Anctil, E., Sylla, M., Zaidan, S., Chartrand-Lefebvre, C., Bunet, R., Ramani, H., Sadouni, M., Boldeanu, I., Chamberland, A., Lesage, S., Baril, J.-G., Trottier, B., Thomas, R., Gonzalez, E., Filali-Mouhim, A., Goulet, J.-P., Martinson, J. A., Kassaye, S., Karim, R., Kizer, J. R., French, A. L., Gange, S. J., Ancuta, P., Routy, J.-P., Hanna, D. B., Kaplan, R. C., Chomont, N., Landay, A. L. & Tremblay, C. L. (2021). Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis. Frontiers in immunology, vol. 12, p. 664371.
  8. Vaillancourt, M., Hubert, A., Subra, C., Boucher, J., Bazié, W. W., Vitry, J., Berrazouane, S., Routy, J.-P., Trottier, S., Tremblay, C., Jenabian, M.-A., Benmoussa, A., Provost, P., Tessier, P. A. & Gilbert, C. (2021). Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA. Pathogens (Basel, Switzerland), vol. 10.
  9. Bazié, W. W., Goyer, B., Boucher, J., Zhang, Y., Planas, D., Chatterjee, D., Routy, J.-P., Alary, M., Ancuta, P. & Gilbert, C. (2021). Diurnal Variation of Plasma Extracellular Vesicle Is Disrupted in People Living with HIV. Pathogens (Basel, Switzerland), vol. 10.
  10. Isnard, S., Lin, J., Bu, S., Fombuena, B., Royston, L. & Routy, J.-P. (2021). Gut Leakage of Fungal-Related Products: Turning Up the Heat for HIV Infection. Frontiers in immunology, vol. 12, p. 656414.
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