Lab Information

Dr. Inés Colmegna

Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 E03.5151 (modules O, P, Q, R) /  #35404


Immunology • arthritis • aging • stem cells

Research Interests

My research focuses on understanding the mechanisms underlying the development and perpetuation of the most common form of inflammatory polyarthritis: rheumatoid arthritis. Specifically, we study the impact of aging on human immune and stem cell function and how aging promotes the disruption of immune tolerance increasing the risk of developing autoimmune disorders.

Team Members

Name Position
Lora, Maximilien Research Assistant
Morozan, Arina MSc Student
Brizio, Marianela MSc Student
Anaya, Ingrid MSc Student
Flores, Brendan Undergraduate

Latest Publications

  1. Zeng, Y., Zhao, K., Oros Klein, K., Shao, X., Fritzler, M. J., Hudson, M., Colmegna, I., Pastinen, T., Bernatsky, S. & Greenwood, C. M. T. (2021). Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals. Genes, vol. 12.
  2. Hitchon, C. A., Mody, G. M., Feldman, C. H., Lau, Y., Shi, S., Meltzer, M., Scuccimarri, R., Weinblatt, M. E. & Colmegna, I. (2021). Perceptions and Challenges Experienced by African Physicians When Prescribing Methotrexate for Rheumatic Disease: An Exploratory Study. ACR open rheumatology, vol. 3, p. 522-530.
  3. Colmegna, I., Valerio, V., Boucher, V. G., Lacoste, G., Labbe, S., Lavoie, K. L., Hazel, E., Ward, B., Hudson, M. & Pelaez, S. (2021). Barriers and facilitators to influenza and pneumococcal vaccine hesitancy in rheumatoid arthritis: a qualitative study. Rheumatology (Oxford, England).
  4. Hazlewood, G. S., Pardo Pardo, J., Barnabe, C., Schieir, O., Barber, C. E. H., Bernatsky, S., Colmegna, I., Hitchon, C., Loeb, M., Mertz, D., Proulx, L., Richards, D. P., Scuccimarri, R., Tugwell, P., Schünemann, H. J., Mirza, R. D., Zhou, A. L., Nikolic, R. P. A., Thomas, M., Chase, H., Ejaredar, M. & Nieuwlaat, R. (2021). Canadian Rheumatology Association Recommendation for the Use of COVID-19 Vaccination for Patients With Autoimmune Rheumatic Diseases. The Journal of rheumatology, vol. 48, p. 1330-1339.
  5. Hoa, S., Laaouad, L., Roberts, J., Ennis, D., Ye, C., Al Jumaily, K., Pope, J., Nevskaya, T., Saltman, A., Himmel, M., Rottapel, R., Ly, C., Colmegna, I., Fifi-Mah, A., Maltez, N., Tisseverasinghe, A., Hudson, M. & Jamal, S. (2021). Preexisting autoimmune disease and immune-related adverse events associated with anti-PD-1 cancer immunotherapy: a national case series from the Canadian Research Group of Rheumatology in Immuno-Oncology. Cancer immunology, immunotherapy : CII, vol. 70, p. 2197-2207.
  6. Cheng, A., Choi, D., Lora, M., Shum-Tim, D., Rak, J. & Colmegna, I. (2020). Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Stem cell research & therapy, vol. 11, p. 539.
  7. Valerio, V., Bazan, M. C., Wang, M., Mazer, B. D., Pineau, C. A., Hazel, E. M., Bernatsky, S., Ward, B. J. & Colmegna, I. (2021). A multimodal intervention increases influenza vaccine uptake in rheumatoid arthritis. Clinical rheumatology, vol. 40, p. 575-579.
  8. Lopez-Olivo, M. A., Pratt, G., Suarez-Almazor, M. E., Colmegna, I., Karpes, A. R., Ruyu Qi, S., Zamora, N. V. & Sharma, R. (2020). Reply. Arthritis care & research, vol. 72, p. 1828-1829.
  9. Zhao, N., Smargiassi, A., Colmegna, I., Hudson, M., Fritzler, M. & Bernatsky, S. (2020). Sunlight exposure, sun-protective behaviour, and anti-citrullinated protein antibody positivity: A general population-based study in Quebec, Canada. Arthritis care & research.
  10. Maltez, N., Puyade, M., Wang, M., Lansiaux, P., Marjanovic, Z., Charles, C., Steele, R., Baron, M., Colmegna, I., Hudson, M., Farge, D. & Canadian Scleroderma Research Group and the MATHEC-SFGMTC Network (2021). Association of Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis With Marked Improvement in Health-Related Quality of Life. Arthritis & rheumatology (Hoboken, N.J.), vol. 73, p. 305-314.
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