Lab Information

Dr. Silvia Vidal

Investigator
McGill University
Department of Human Genetics (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 367

Keywords

Mouse genetic models • virus infections • innate immunity • complex traits analysis • primary human cells

Research Interests

My research focuses on why certain individuals are extremely vulnerable to a viral infection and develop severe diseases whereas others remain unharmed when exposed to the same pathogen. Herpes simplex encephalitis, influenza pneumonia, and viral myocarditis are severe but relatively rare occurrences of infections with viruses that are common in the general population. My laboratory uses specialized mouse genetic models that replicate human diseases to parse genes, proteins, and cells of the host that are implicated in the infection process. We have found proteins involved in virus recognition, signal transduction kinases, and transcription factors, which are critical to the outcome of infection. With this information, we search for small molecules that target those mechanisms to improve virus-induced pathologies.


Team Members

Name Position
Mancini, Mathieu PhD Student
Barone, Natasha MSc Student

Latest Publications

  1. Xu, G., van Bruggen, R., Gualtieri, C. O., Moradin, N., Fois, A., Vallerand, D., De Sa Tavares Russo, M., Bassenden, A., Lu, W., Tam, M., Lesage, S., Girouard, H., Avizonis, D. Z., Deblois, G., Prchal, J. T., Stevenson, M., Berghuis, A., Muir, T., Rabinowitz, J., Vidal, S. M., Fodil, N. & Gros, P. (2020). Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. Cell reports, vol. 32, p. 108170.
  2. Mancini, M. & Vidal, S. M. (2020). Mechanisms of Natural Killer Cell Evasion Through Viral Adaptation. Annual review of immunology, vol. 38, p. 511-539.
  3. Kennedy, J. M., Georges, A., Bassenden, A. V., Vidal, S. M., Berghuis, A. M., Taniuchi, I., Majewski, J., Lathrop, M., Behr, M. A., Langlais, D. & Gros, P. (2020). ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis. Infection and immunity, vol. 88.
  4. Chehboun, S., Leiva-Torres, G. A., Charbonneau, B., Eveleigh, R., Bourque, G. & Vidal, S. M. (2020). A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation. Genes and immunity, vol. 21, p. 136-141.
  5. Yuki, K. E., Marei, H., Fiskin, E., Eva, M. M., Gopal, A. A., Schwartzentruber, J. A., Majewski, J., Cellier, M., Mandl, J. N., Vidal, S. M., Malo, D. & Dikic, I. (2019). CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nature microbiology, vol. 4, p. 1516-1531.
  6. Železnjak, J., Lisnić, V. J., Popović, B., Lisnić, B., Babić, M., Halenius, A., L'Hernault, A., Roviš, T. L., Hengel, H., Erhard, F., Redwood, A. J., Vidal, S. M., Dölken, L., Krmpotić, A. & Jonjić, S. (2019). The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. The Journal of experimental medicine, vol. 216, p. 1809-1827.
  7. Mancini, M., Caignard, G., Charbonneau, B., Dumaine, A., Wu, N., Leiva-Torres, G. A., Gerondakis, S., Pearson, A., Qureshi, S. T., Sladek, R. & Vidal, S. M. (2019). Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. Journal of immunology (Baltimore, Md. : 1950), vol. 202, p. 1479-1493.
  8. Mancini, M. & Vidal, S. M. (2018). Insights into the pathogenesis of herpes simplex encephalitis from mouse models. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 29, p. 425-445.
  9. Rodrigue-Gervais, I. G., Doiron, K., Champagne, C., Mayes, L., Leiva-Torres, G. A., Vanié, P., Douglas, T., Vidal, S. M., Alnemri, E. S. & Saleh, M. (2018). The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. Scientific reports, vol. 8, p. 8446.
  10. Leiva-Torres, G. A., Nebesio, N. & Vidal, S. M. (2017). Discovery of Variants Underlying Host Susceptibility to Virus Infection Using Whole-Exome Sequencing. Methods in molecular biology (Clifton, N.J.), vol. 1656, p. 209-227.
More on PubMed 



See also

Card image
Danielle
Malo


See profile
Card image
Marcel
Behr


See profile
Card image
Danuta
Radzioch


See profile
Card image
Chen
Liang


See profile

 

Latest News

Events/Seminars

Research groups

Careers