Lab Information

Dr. Nicole Bernard

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 EM3.3238
 E03.3380 (modules M, N, O, P) /  #42697

Keywords

HIV/AIDS • immunology • virology • host responses to HIV • NK cells • NK cell receptors • T cells

Research Interests

My research focuses on why some people who are exposed to HIV multiple times do not become infected. I am also interested in understanding why a small subset of HIV infected people control their HIV infection without treatment and exhibit very slow HIV disease progression. We have found evidence that Natural Killer cells play a role in protection from infection and slow time to AIDS in those infected. One of our research goals is to understand the mechanisms underlying these favorable responses to HIV.


Team Members

Name Position
Kant, Sanket PhD Student
Mabanga, Tara Laboratory Technician
Dupuy, Franck Research Associate
Aslulami, Khlood PhD Student
Gilbert, Louise Research Assistant

Latest Publications

  1. Meziane, O., Alexandrova, Y., Olivenstein, R., Dupuy, F. P., Salahuddin, S., Thomson, E., Orlova, M., Schurr, E., Ancuta, P., Durand, M., Chomont, N., Estaquier, J., Bernard, N. F., Costiniuk, C. T. & Jenabian, M.-A. (2021). Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy. Journal of immunology (Baltimore, Md. : 1950), vol. 206, p. 641-651.
  2. Kant, S., Zhang, N., Barbé, A., Routy, J.-P., Tremblay, C., Thomas, R., Szabo, J., Côté, P., Trottier, B., LeBlanc, R., Rouleau, D., Harris, M., Dupuy, F. P. & Bernard, N. F. (2020). Polyfunctional Fc Dependent Activity of Antibodies to Native Trimeric Envelope in HIV Elite Controllers. Frontiers in immunology, vol. 11, p. 583820.
  3. Isnard, S., Ramendra, R., Lin, J., Kant, S., Fombuena, B., Ouyang, J., Peng, X., El Far, M., Tremblay, C., Bernard, N. F., Routy, J.-P. & Canadian cohort of HIV+ slow progressors (2020). Anti-CMV IgG is linked to CD4 T-cell count decay in HIV elite controllers. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  4. Niessl, J., Baxter, A. E., Morou, A., Brunet-Ratnasingham, E., Sannier, G., Gendron-Lepage, G., Richard, J., Delgado, G.-G., Brassard, N., Turcotte, I., Fromentin, R., Bernard, N. F., Chomont, N., Routy, J.-P., Dubé, M., Finzi, A. & Kaufmann, D. E. (2020). Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy. EBioMedicine, vol. 54, p. 102727.
  5. Dupuy, F. P., Kant, S., Barbé, A., Routy, J.-P., Bruneau, J., Lebouché, B., Tremblay, C., Pazgier, M., Finzi, A. & Bernard, N. F. (2019). Antibody-Dependent Cellular Cytotoxicity-Competent Antibodies against HIV-1-Infected Cells in Plasma from HIV-Infected Subjects. mBio, vol. 10.
  6. Kiani, Z., Dupuy, F. P., Bruneau, J., Lebouché, B., Retière, C., Geraghty, D. E. & Bernard, N. F. (2019). The Education of NK Cells Determines Their Responsiveness to Autologous HIV-Infected CD4 T Cells. Journal of virology, vol. 93.
  7. Isnard, S., Ramendra, R., Dupuy, F. P., Lin, J., Fombuena, B., Kokinov, N., Kema, I., Jenabian, M.-A., Lebouché, B., Costiniuk, C. T., Ancuta, P., Bernard, N. F., Silverman, M. S., Lakatos, P. L., Durand, M., Tremblay, C., Routy, J.-P. & Montreal Primary HIV Infection Study, the Canadian Cohort of HIV+ Slow Progressors, and the Canadian HIV and Aging Cohort Groups (2020). Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus. The Journal of infectious diseases, vol. 221, p. 110-121.
  8. Kiani, Z., Bruneau, J., Geraghty, D. E. & Bernard, N. F. (2019). HLA-F on Autologous HIV-Infected Cells Activates Primary NK Cells Expressing the Activating Killer Immunoglobulin-Like Receptor KIR3DS1. Journal of virology, vol. 93.
  9. Kant, S., Zhang, N., Routy, J.-P., Tremblay, C., Thomas, R., Szabo, J., Côté, P., Trottier, B., LeBlanc, R., Rouleau, D., Harris, M., Dupuy, F. P. & Bernard, N. F. (2019). Quantifying Anti-HIV Envelope-Specific Antibodies in Plasma from HIV Infected Individuals. Viruses, vol. 11.
  10. Mehraj, V., Ramendra, R., Isnard, S., Dupuy, F. P., Ponte, R., Chen, J., Kema, I., Jenabian, M.-A., Costinuik, C. T., Lebouché, B., Thomas, R., Coté, P., Leblanc, R., Baril, J.-G., Durand, M., Chartrand-Lefebvre, C., Tremblay, C., Ancuta, P., Bernard, N. F., Sheppard, D. C., Routy, J.-P. & Montreal Primary HIV Infection Study and Canadian HIV and Aging Cohort Study Groups (2020). Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 70, p. 232-241.
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See also

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Jean-Pierre
Routy


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Bertrand
Lebouché


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Cecilia
Costiniuk


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Donald
Sheppard


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Peter
Lakatos


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Paul
Brassard


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