Lab Information

Dr. Ken Dewar

Investigator
McGill University
Department of Human Genetics (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 7413

Keywords

Genomics • comparative genomics • DNA sequence analysis

Research Interests

My research interests straddle advanced DNA sequencing technologies and bioinformatics. I am interested in strategies for genome assembly and how to use bioinformatics to know that “we have got it right”, then using the assemblies as references to discern genetic variation and to annotate genetic processes. I firmly believe that genomics is not only transforming human biomedical research, but is revolutionizing research across the full breadth of life sciences. The ability to use core instrumentation and expertise throughout biology is underpinning new advances in the fields of research including, but not limited to human and animal medicine, food safety, environmental assessment, and biotechnology.


Team Members

Name Position
D'Iorio, Matthew PhD Student
Lee, Sebastian Chan Ho MSc Student

Latest Publications

  1. Cavalcanti, G. S., Wasserscheid, J., Dewar, K. & Shikuma, N. J. (2020). Complete Genome Sequences of Two Marine Biofilm Isolates, Leisingera sp. nov. Strains 201A and 204H, Novel Representatives of the Roseobacter Group. Microbiology resource announcements, vol. 9.
  2. Bayega, A., Djambazian, H., Tsoumani, K. T., Gregoriou, M.-E., Sagri, E., Drosopoulou, E., Mavragani-Tsipidou, P., Giorda, K., Tsiamis, G., Bourtzis, K., Oikonomopoulos, S., Dewar, K., Church, D. M., Papanicolaou, A., Mathiopoulos, K. D. & Ragoussis, J. (2020). De novo assembly of the olive fruit fly (Bactrocera oleae) genome with linked-reads and long-read technologies minimizes gaps and provides exceptional Y chromosome assembly. BMC genomics, vol. 21, p. 259.
  3. Péan, N., Le Lay, A., Brial, F., Wasserscheid, J., Rouch, C., Vincent, M., Myridakis, A., Hedjazi, L., Dumas, M.-E., Grundberg, E., Lathrop, M., Magnan, C., Dewar, K. & Gauguier, D. (2020). Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia, vol. 63, p. 1223-1235.
  4. Hebert, F. O., Freschi, L., Blackburn, G., Béliveau, C., Dewar, K., Boyle, B., Gundersen-Rindal, D. E., Sparks, M. E., Cusson, M., Hamelin, R. C. & Levesque, R. C. (2019). Expansion of LINEs and species-specific DNA repeats drives genome expansion in Asian Gypsy Moths. Scientific reports, vol. 9, p. 16413.
  5. Desloges, I., Taylor, J. A., Leclerc, J.-M., Brannon, J. R., Portt, A., Spencer, J. D., Dewar, K., Marczynski, G. T., Manges, A., Gruenheid, S., Le Moual, H. & Thomassin, J.-L. (2019). Identification and characterization of OmpT-like proteases in uropathogenic Escherichia coli clinical isolates. MicrobiologyOpen, vol. 8, p. e915.
  6. Minerbi, A., Gonzalez, E., Brereton, N. J. B., Anjarkouchian, A., Dewar, K., Fitzcharles, M.-A., Chevalier, S. & Shir, Y. (2019). Altered microbiome composition in individuals with fibromyalgia. Pain, vol. 160, p. 2589-2602.
  7. Lypaczewski, P., Hoshizaki, J., Zhang, W.-W., McCall, L.-I., Torcivia-Rodriguez, J., Simonyan, V., Kaur, A., Dewar, K. & Matlashewski, G. (2018). A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence. Scientific reports, vol. 8, p. 16549.
  8. Svardal, H., Jasinska, A. J., Apetrei, C., Coppola, G., Huang, Y., Schmitt, C. A., Jacquelin, B., Ramensky, V., Müller-Trutwin, M., Antonio, M., Weinstock, G., Grobler, J. P., Dewar, K., Wilson, R. K., Turner, T. R., Warren, W. C., Freimer, N. B. & Nordborg, M. (2018). Publisher Correction: Ancient hybridization and strong adaptation to viruses across African vervet monkey populations. Nature genetics, vol. 50, p. 1617.
  9. Teatero, S., McGeer, A., Tyrrell, G. J., Hoang, L., Smadi, H., Domingo, M.-C., Levett, P. N., Finkelstein, M., Dewar, K., Plevneshi, A., Athey, T. B. T., Gubbay, J. B., Mulvey, M. R., Martin, I., Demczuk, W. & Fittipaldi, N. (2018). Canada-Wide Epidemic of emm74 Group A Streptococcus Invasive Disease. Open forum infectious diseases, vol. 5, p. ofy085.
  10. Jasinska, A. J., Zelaya, I., Service, S. K., Peterson, C. B., Cantor, R. M., Choi, O.-W., DeYoung, J., Eskin, E., Fairbanks, L. A., Fears, S., Furterer, A. E., Huang, Y. S., Ramensky, V., Schmitt, C. A., Svardal, H., Jorgensen, M. J., Kaplan, J. R., Villar, D., Aken, B. L., Flicek, P., Nag, R., Wong, E. S., Blangero, J., Dyer, T. D., Bogomolov, M., Benjamini, Y., Weinstock, G. M., Dewar, K., Sabatti, C., Wilson, R. K., Jentsch, J. D., Warren, W., Coppola, G., Woods, R. P. & Freimer, N. B. (2017). Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nature genetics, vol. 49, p. 1714-1721.
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