Lab Information

Dr. Donald Sheppard

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 EM3.3212
 E03.3126 (modules A, B, C, D) /  #76119

Keywords

Medical mycology • aspergillus • biofilms • host-pathogen interactions

Research Interests

My research focuses on understanding how molds and other fungi cause human disease. Recently, our laboratory discovered that fungi secrete sugars that can act as a glue in order to help fungi attach to human lung cells and hide from the immune system during lung infections. My research focuses on fungi that infect humans. In particular, we focus on the common mold Aspergillus fumigatus, which causes pneumonia in patients who have received chemotherapy, organ transplantation, bone marrow transplantation or high dose cortisone therapy. Despite the use of current antifungal drugs, this pneumonia is fatal for more than half the affected patients. Our group is working to identify how this fungus invades human tissues in order to develop new, more effective antifungal therapies to prevent and cure this aggressive and common condition.


Team Members

Name Position
Le Mauff, Francois Research Associate
Ostapska, Hanna PhD Student
Millette, Pierre-Guy PhD Student
Zacharias, Caitlin PhD Student
Gravelat, Fabrice Research Associate
Khalife, Sarah MSc Student
Chabot, Josée Manager (Research)
Lacdao, Ira Research Assistant
Saldanha, Marcus Undergraduate
Firer, David Undergraduate
Lyu, Yunfan Undergraduate

Latest Publications

  1. Demir, K. K., Butler-Laporte, G., Del Corpo, O., Ekmekjian, T., Sheppard, D. C., Lee, T. C. & Cheng, M. P. (2021). Comparative Effectiveness of Amphotericin B, Azoles, and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis: A Systematic Review and Network Meta-Analysis. Mycoses.
  2. Demina, E. P., Smutova, V., Pan, X., Fougerat, A., Guo, T., Zou, C., Chakraberty, R., Snarr, B. D., Shiao, T. C., Roy, R., Orekhov, A. N., Miyagi, T., Laffargue, M., Sheppard, D. C., Cairo, C. W. & Pshezhetsky, A. V. (2021). Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low-Density Lipoproteins and Increasing Their Uptake by Macrophages. Journal of the American Heart Association, p. e018756.
  3. Ralph, B. & Sheppard, D. C. (2021). A Murine Model for Chronic A. fumigatus Airway Infections. Methods in molecular biology (Clifton, N.J.), vol. 2260, p. 215-224.
  4. Chen, Y., Le Mauff, F., Wang, Y., Lu, R., Sheppard, D. C., Lu, L. & Zhang, S. (2020). The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in Aspergillus fumigatus. mBio, vol. 11.
  5. Deshmukh, H., Speth, C., Sheppard, D. C., Neurauter, M., Würzner, R., Lass-Flörl, C. & Rambach, G. (2020). Aspergillus-Derived Galactosaminogalactan Triggers Complement Activation on Human Platelets. Frontiers in immunology, vol. 11, p. 550827.
  6. Salmanton-García, J., Koehler, P., Kindo, A., Falces-Romero, I., García-Rodríguez, J., Ráčil, Z., Chen, S.-C., Klimko, N., Desoubeaux, G., Thompson, G. R., Benítez-Peñuela, M.-Á., Rodríguez, J.-Y., Sheppard, D. C., Hoenigl, M., Le Govic, Y., Badali, H., Baddley, J. W., Chander, J., Ingram, P. R., Pakstis, D. L., Mellinghoff, S. C., Atıcı, S., Cesaro, S., Chakrabarti, A., Dupont, D., González, G. M., Hatvani, L., Herbrecht, R., Klyasova, G., Lass-Flörl, C., Mareș, M., Mullane, K., Vinh, D. C., Wisplinghoff, H., Lackner, M., Cornely, O. A., Seidel, D. & ECMM/ISHAM working group (2020). Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections. The Journal of infection, vol. 81, p. 802-815.
  7. Snarr, B. D., St-Pierre, G., Ralph, B., Lehoux, M., Sato, Y., Rancourt, A., Takazono, T., Baistrocchi, S. R., Corsini, R., Cheng, M. P., Sugrue, M., Baden, L. R., Izumikawa, K., Mukae, H., Wingard, J. R., King, I. L., Divangahi, M., Satoh, M. S., Yipp, B. G., Sato, S. & Sheppard, D. C. (2020). Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection. PLoS pathogens, vol. 16, p. e1008741.
  8. Horianopoulos, L. C., Gluck-Thaler, E., Benoit Gelber, I., Cowen, L. E., Geddes-McAlister, J., Landry, C. R., Schwartz, I. S., Scott, J. A., Sellam, A., Sheppard, D. C., Spribille, T., Subramaniam, R., Walker, A. K., Harris, S. D., Shapiro, R. S. & Gerstein, A. C. (2021). The Canadian Fungal Research Network: current challenges and future opportunities. Canadian journal of microbiology, vol. 67, p. 13-22.
  9. Del Corpo, O., Butler-Laporte, G., Sheppard, D. C., Cheng, M. P., McDonald, E. G. & Lee, T. C. (2020). Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 26, p. 1137-1143.
  10. Bamford, N. C., Le Mauff, F., Van Loon, J. C., Ostapska, H., Snarr, B. D., Zhang, Y., Kitova, E. N., Klassen, J. S., Codée, J. D. C., Sheppard, D. C. & Howell, P. L. (2020). Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. Nature communications, vol. 11, p. 2450.
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