Lab Information

Dr. Danuta Radzioch

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 EM2.3242
 E02.5119 (modules A, B) /  #44516
 E02.5125 (modules C, D)

Keywords

Inflammation • animal models • translational research • lipid imbalance • gene expression regulation

Research Interests

My research focuses on the molecular mechanisms involved in the regulation of inflammatory response in asthma, cystic fibrosis and cancer. It involves preclinical studies testing novel anti-inflammatory drugs on cystic fibrosis lung disease, allergic asthma and colon cancer. Our research team has discovered pharmacological intervention which enables to normalize fatty acids metabolism distortion during chronic bacterial infections in cystic fibrosis, chronic allergic responses, and acute spinal cord injuries leading to permanent motor dysfunction. My laboratory has developed mouse models of cystic fibrosis lung disease, mouse models of allergic asthma, genetically controlled airway hyperresponsiveness and atopy, and mouse models of colon cancer. Our research also explores the role of chromatin remodelling in the regulation of transcriptional regulation and the mechanisms of posttranscriptional control of genes involved in the control of inflammatory response. We have identified drugs and therapies which can improve Cystic fibrosis lung disease and allergic asthma. One of the drugs are working on has received an orphan drug designation from the FDA and we are in the final stage of preparing for a Phase 1b clinical trial to test its safety and therapeutic potential in patients suffering from cystic fibrosis.


Team Members

Name Position
Youssef, Mina PhD Student
Dumut, Catalina MSc Student
Shah, Juhi Undergraduate
Paun, Radu Alex PhD Student
Ondra, Martin PhD Student
Vendrely, Veronique Visiting Professor
Dajani, Haya Undergraduate
Kohen, Scott Undergraduate
Centorame, Amanda MSc Student

Latest Publications

  1. Hennemann, L. C., LaFayette, S. L., Malet, J. K., Bortolotti, P., Yang, T., McKay, G. A., Houle, D., Radzioch, D., Rousseau, S. & Nguyen, D. (2021). LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation. PLoS pathogens, vol. 17, p. e1009375.
  2. Veltman, M., De Sanctis, J. B., Stolarczyk, M., Klymiuk, N., Bähr, A., Brouwer, R. W., Oole, E., Shah, J., Ozdian, T., Liao, J., Martini, C., Radzioch, D., Hanrahan, J. W. & Scholte, B. J. (2021). CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells. Frontiers in physiology, vol. 12, p. 619442.
  3. De Sanctis, J. B., Dumut, D. C., Radzioch, D. & Hajdúch, M. (2020). Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults. Nutrients, vol. 12.
  4. Garić, D., Dumut, D. C., Shah, J., De Sanctis, J. B. & Radzioch, D. (2020). The role of essential fatty acids in cystic fibrosis and normalizing effect of fenretinide. Cellular and molecular life sciences : CMLS, vol. 77, p. 4255-4267.
  5. Youssef, M., De Sanctis, J. B., Shah, J., Dumut, D. C., Hajduch, M., Petrof, B. J. & Radzioch, D. (2020). Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis. Lung, vol. 198, p. 459-469.
  6. Youssef, M., De Sanctis, J. B., Shah, J., Dumut, D. C., Hajduch, M., Naumova, A. K. & Radzioch, D. (2020). Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance. The Journal of pharmacology and experimental therapeutics, vol. 373, p. 476-487.
  7. Youssef, M., De Sanctis, J. B., Kanagaratham, C., Tao, S., Ahmed, E. & Radzioch, D. (2020). Efficacy of Optimized Treatment Protocol Using LAU-7b Formulation against Ovalbumin (OVA) and House Dust Mite (HDM) -Induced Allergic Asthma in Atopic Hyperresponsive A/J Mice. Pharmaceutical research, vol. 37, p. 31.
  8. Garić, D., De Sanctis, J. B., Dumut, D. C., Shah, J., Peña, M. J., Youssef, M., Petrof, B. J., Kopriva, F., Hanrahan, J. W., Hajduch, M. & Radzioch, D. (2020). Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction. Biochimica et biophysica acta. Molecular and cell biology of lipids, vol. 1865, p. 158538.
  9. Garić, D., De Sanctis, J. B., Shah, J., Dumut, D. C. & Radzioch, D. (2019). Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain. Progress in lipid research, p. 100998.
  10. Garić, D., De Sanctis, J. B., Shah, J., Dumut, D. C. & Radzioch, D. (2019). Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain. Progress in lipid research, vol. 74, p. 130-144.
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