Lab Information

Dr. Chen Liang

Associate Investigator
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

HIV • COVID-19 • SARS-CoV • innate immunity • interferon • antivirals

Research Interests

My research aims to understand the host innate immune responses to viral infections. My team uses the findings to understand viral pathogenesis and transmission and to guide the development of effective antiviral therapeutics. Specifically, we investigate how host cells produce antiviral interferons in response to infections by HIV or SARS-CoV-2, and how these two highly pathogenic viruses overcome and evade this first line of host defense. We are dedicated to the discovery of new HIV treatments and the compounds that can effectively inhibit SARS-CoV-2 and thus cure COVID-19. My lab has also pioneered the application of the CRISPR gene editing tool in curing HIV infection.


Team Members

Name Position
Wang, Zhen Research Associate

Latest Publications

  1. Zhao, J., Guo, S., Yi, D., Li, Q., Ma, L., Zhang, Y., Wang, J., Li, X., Guo, F., Lin, R., Liang, C., Liu, Z. & Cen, S. (2021). A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral research, p. 105078.
  2. Ma, L., Chen, S., Wang, Z., Guo, S., Zhao, J., Yi, D., Li, Q., Liu, Z., Guo, F., Li, X., Jia, P., Ding, J., Liang, C. & Cen, S. (2021). The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR. Virologica Sinica.
  3. Xu, F., Liu, X., Zhang, D., Zhao, F., Fan, Z., Hu, S., Mei, S., Huang, Y., Sun, H., Wei, L., Guo, L., Wang, J., Cen, S., Liang, C. & Guo, F. (2021). The engineered MARCH8-resistant VSV glycoprotein enhances lentiviral vector transduction. Human gene therapy.
  4. Li, Q., Yi, D., Lei, X., Zhao, J., Zhang, Y., Cui, X., Xiao, X., Jiao, T., Dong, X., Zhao, X., Zeng, H., Liang, C., Ren, L., Guo, F., Li, X., Wang, J. & Cen, S. (2021). Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase. Acta pharmaceutica Sinica. B.
  5. Sun, H., Huang, Y., Mei, S., Xu, F., Liu, X., Zhao, F., Yin, L., Zhang, D., Wei, L., Wu, C., Ma, S., Wang, J., Cen, S., Liang, C., Hu, S. & Guo, F. (2021). A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA. Cell reports, vol. 34, p. 108586.
  6. Wang, Z., Chai, K., Liu, Q., Yi, D.-R., Pan, Q., Huang, Y., Tan, J., Qiao, W., Guo, F., Cen, S. & Liang, C. (2020). HIV-1 resists MxB inhibition of viral Rev protein. Emerging microbes & infections, vol. 9, p. 2030-2045.
  7. Yi, D., Li, Q., Pang, L., Wang, Y., Zhang, Y., Duan, Z., Liang, C. & Cen, S. (2020). Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus. Frontiers in microbiology, vol. 11, p. 1440.
  8. Yin, L., Zhao, F., Sun, H., Wang, Z., Huang, Y., Zhu, W., Xu, F., Mei, S., Liu, X., Zhang, D., Wei, L., Cen, S., Hu, S., Liang, C. & Guo, F. (2020). CRISPR-Cas13a Inhibits HIV-1 Infection. Molecular therapy. Nucleic acids, vol. 21, p. 147-155.
  9. Beitari, S., Pan, Q., Finzi, A. & Liang, C. (2020). Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection. Journal of virology, vol. 94.
  10. Xu, F., Zhao, F., Zhao, X., Zhang, D., Liu, X., Hu, S., Mei, S., Fan, Z., Huang, Y., Sun, H., Wei, L., Wu, C., Li, Q., Wang, J., Cen, S., Liang, C. & Guo, F. (2020). Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid. The Journal of biological chemistry, vol. 295, p. 6447-6456.
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Silvia
Vidal


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