Lab Information

Dr. Cecilia Costiniuk

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 40%
 Epidemiology: 20%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 EM2.3226
 E03.3374 (modules K, L)

Keywords

HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity

Research Interests

My research focuses on potential factors associated with accelerated chronic lung disease in HIV infection. Despite the success of highly active antiretroviral therapy (HAART), individuals with HIV appear to be at increased risk of chronic lung disease which cannot be accounted for by smoking alone. I am interested in the role of the lungs as reservoirs of HIV infection, in addition to the effect of pulmonary inflammation on the size of the lung HIV reservoir in individuals on effective HAART. I am also interested in pulmonary immune abnormalities in the context of HIV infection.


Team Members

Name Position
Caballero, Ramon Edwin PhD Student
Grech, Sarah MSc Student

Latest Publications

  1. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2021). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, p. 1-7.
  2. Rothan, C., Yero, A., Shi, T., Farnos, O., Chartrand-Lefebvre, C., El-Far, M., Costiniuk, C. T., Tsoukas, C., Tremblay, C., Durand, M., Jenabian, M.-A. & Canadian HIV and Aging Cohort Study (2021). ART-treated HIV-infected adults with coronary artery disease are characterized by a distinctive regulatory T-cell signature. AIDS (London, England), vol. 35, p. 1003-1014.
  3. Sandstrom, T. S., Ranganath, N., Burke Schinkel, S. C., Salahuddin, S., Meziane, O., Côté, S. C., Costiniuk, C. T., Jenabian, M.-A. & Angel, J. B. (2021). HIV-infected macrophages are infected and killed by the interferon-sensitive Rhabdovirus, MG1. Journal of virology, vol. 95.
  4. Costiniuk, C. T., Bessissow, T., Isnard, S. & Routy, J.-P. (2021). Use of various immunotherapies for refractory ulcerative colitis in a person living with HIV: a case report. Oxford medical case reports, vol. 2021, p. omaa131.
  5. Lebouché, B., Yero, A., Shi, T., Farnos, O., Singer, J., Kema, I., Costiniuk, C. T., Thomas, R., Brouillette, M.-J., Engler, K., Routy, J.-P., Jenabian, M.-A. & CTN PT006 Study Group (2021). Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy. HIV research & clinical practice, p. 1-9.
  6. Meziane, O., Alexandrova, Y., Olivenstein, R., Dupuy, F. P., Salahuddin, S., Thomson, E., Orlova, M., Schurr, E., Ancuta, P., Durand, M., Chomont, N., Estaquier, J., Bernard, N. F., Costiniuk, C. T. & Jenabian, M.-A. (2021). Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy. Journal of immunology (Baltimore, Md. : 1950), vol. 206, p. 641-651.
  7. Lodge, R., Bellini, N., Laporte, M., Salahuddin, S., Routy, J.-P., Ancuta, P., Costiniuk, C. T., Jenabian, M.-A. & Cohen, É. A. (2020). Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107. mBio, vol. 11.
  8. Meziane, O., Salahuddin, S., Pham, T. N. Q., Farnos, O., Pagliuzza, A., Olivenstein, R., Thomson, E., Alexandrova, Y., Orlova, M., Schurr, E., Ancuta, P., Haddad, É., Chomont, N., Cohen, E. A., Jenabian, M.-A. & Costiniuk, C. T. (2020). HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo. Journal of virology, vol. 94.
  9. Costiniuk, C. T. & Jenabian, M.-A. (2020). Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?. Cytokine & growth factor reviews, vol. 53, p. 63-65.
  10. Bichara, B., Routy, J.-P., Ezer, N. & Costiniuk, C. T. (2020). Primary lung cancer diagnoses in people living with HIV in a large clinical centre in Montreal, Canada over 3 decades. AIDS care, vol. 32, p. 979-983.
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See also

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Jean-Pierre
Routy


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Bertrand
Lebouché


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Marina
Klein


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Joseph
Cox


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Marie-Josée
Brouillette


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Nicole
Bernard


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