Lab Information

Dr. Danielle Malo

Investigator
McGill University
Department of Human Genetics (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Salmonella • typhoid • complex disease • animal model • mutagenesis

Research Interests

My research focuses on identifying and characterizing genes involved in the host immune response to pathogenic Salmonella using mouse models of the disease. Salmonella are ubiquitous, facultative intracellular Gram-negative bacteria causing human diseases (typhoid fever and salmonellosis) of increasingly important public health concern both in developed and developing countries. Salmonella Typhi is the causative agent of typhoid fever and Salmonella Typhimurium and Enteritidis are associated with frequent outbreaks of food-borne gastroenteritis (salmonellosis). Multidrug resistant non-typhoidal Salmonella (NTS) infections are also increasingly frequent in developing countries. My lab is using different models of infection (systemic, chronic carriage and intestinal infection) and genetic approaches (positional cloning of Mendelian and complex phenotypes and chemical mutagenesis) to study the complex mechanisms underlying the host response to Salmonella infection.


Team Members

Name Position
Li, Zhiwei PhD Student
D'Arcy, Patricia Laboratory Technician
Brillouet, Manon Undergraduate

Latest Publications

  1. Emond-Rheault, J.-G., Hamel, J., Jeukens, J., Freschi, L., Kukavica-Ibrulj, I., Boyle, B., Tamber, S., Malo, D., Franz, E., Burnett, E., Daigle, F., Arya, G., Sanderson, K., Wiedmann, M., Slawson, R. M., Weadge, J. T., Stephan, R., Bekal, S., Gruenheid, S., Goodridge, L. D. & Levesque, R. C. (2020). The Salmonella enterica Plasmidome as a Reservoir of Antibiotic Resistance. Microorganisms, vol. 8.
  2. Crouse, A., Schramm, C., Emond-Rheault, J.-G., Herod, A., Kerhoas, M., Rohde, J., Gruenheid, S., Kukavica-Ibrulj, I., Boyle, B., Greenwood, C. M. T., Goodridge, L. D., Garduno, R., Levesque, R. C., Malo, D. & Daigle, F. (2020). Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence. mSphere, vol. 5.
  3. Zhang, J., Teh, M., Kim, J., Eva, M. M., Cayrol, R., Meade, R., Nijnik, A., Montagutelli, X., Malo, D. & Jaubert, J. (2019). A Loss-of-Function Mutation in the Integrin Alpha L (Itgal) Gene Contributes to Susceptibility to Salmonella enterica Serovar Typhimurium Infection in Collaborative Cross Strain CC042. Infection and immunity, vol. 88.
  4. Yuki, K. E., Marei, H., Fiskin, E., Eva, M. M., Gopal, A. A., Schwartzentruber, J. A., Majewski, J., Cellier, M., Mandl, J. N., Vidal, S. M., Malo, D. & Dikic, I. (2019). CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nature microbiology, vol. 4, p. 1516-1531.
  5. Kang, E., Crouse, A., Chevallier, L., Pontier, S. M., Alzahrani, A., Silué, N., Campbell-Valois, F.-X., Montagutelli, X., Gruenheid, S. & Malo, D. (2018). Enterobacteria and host resistance to infection. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 29, p. 558-576.
  6. Zhang, J., Malo, D., Mott, R., Panthier, J.-J., Montagutelli, X. & Jaubert, J. (2018). Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice. BMC genomics, vol. 19, p. 303.
  7. Emond-Rheault, J.-G., Jeukens, J., Freschi, L., Kukavica-Ibrulj, I., Boyle, B., Dupont, M.-J., Colavecchio, A., Barrere, V., Cadieux, B., Arya, G., Bekal, S., Berry, C., Burnett, E., Cavestri, C., Chapin, T. K., Crouse, A., Daigle, F., Danyluk, M. D., Delaquis, P., Dewar, K., Doualla-Bell, F., Fliss, I., Fong, K., Fournier, E., Franz, E., Garduno, R., Gill, A., Gruenheid, S., Harris, L., Huang, C. B., Huang, H., Johnson, R., Joly, Y., Kerhoas, M., Kong, N., Lapointe, G., Larivière, L., Loignon, S., Malo, D., Moineau, S., Mottawea, W., Mukhopadhyay, K., Nadon, C., Nash, J., Ngueng Feze, I., Ogunremi, D., Perets, A., Pilar, A. V., Reimer, A. R., Robertson, J., Rohde, J., Sanderson, K. E., Song, L., Stephan, R., Tamber, S., Thomassin, P., Tremblay, D., Usongo, V., Vincent, C., Wang, S., Weadge, J. T., Wiedmann, M., Wijnands, L., Wilson, E. D., Wittum, T., Yoshida, C., Youfsi, K., Zhu, L., Weimer, B. C., Goodridge, L. & Levesque, R. C. (2017). A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis. Frontiers in microbiology, vol. 8, p. 996.
  8. Willemetz, A., Beatty, S., Richer, E., Rubio, A., Auriac, A., Milkereit, R. J., Thibaudeau, O., Vaulont, S., Malo, D. & Canonne-Hergaux, F. (2017). Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection. Frontiers in immunology, vol. 8, p. 498.
  9. Beatty, S., Rached-D'Astous, L. & Malo, D. (2017). Complex genetics architecture contributes to Salmonella resistance in AcB60 mice. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 28, p. 38-46.
  10. Duerr, C. U., McCarthy, C. D., Mindt, B. C., Rubio, M., Meli, A. P., Pothlichet, J., Eva, M. M., Gauchat, J.-F., Qureshi, S. T., Mazer, B. D., Mossman, K. L., Malo, D., Gamero, A. M., Vidal, S. M., King, I. L., Sarfati, M. & Fritz, J. H. (2016). Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nature immunology, vol. 17, p. 65-75.
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Silvia
Vidal


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Ken
Dewar


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