Lab Information

Dr. Ciriaco Piccirillo

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 EM2.3248
 E03.5119 (modules A, B, C, D) /  #76391
 E03.5125 (modules E, F) /  #76377
 http://www.piccirillolab.wix.com/piccirillolab

Keywords

Immunology • T cell biology • autoimmune diseases • inflammatory diseases

Research Interests

My research focuses on the regulation of innate and adaptive immune responses mediated by Foxp3+ regulatory T (Treg) cells, a unique population of CD4+ T cells with potent immunosuppressive functions in humans and mice. Normal development and function of Foxp3+ Treg cells is essential for the protection from autoimmune diseases and developmental or functional defects in Treg cells in mice and humans unequivocally provokes many inflammatory and autoimmune diseases. Our research is responsible for many seminal studies over the past decade related to the function and mechanism of action of Treg cells in a variety of animal models, non-human primates and humans. My research program aims to determine whether Treg cell developmental, functional or homeostatic deficiencies trigger various inflammatory disorders, and in particular autoimmune diseases like type 1 diabetes (T1D). My laboratory exploits a spectrum of molecular and cellular approaches to study the development, dynamics and molecular basis of Treg cell function in health and disease.


Team Members

Name Position
Al-Aubodah, Tho-Alfakar PhD Student
Alvarez, Fernando Postdoc
Istomine, Roman PhD Student
Mason, Helen Laboratory Technician
Attias, Mikhael PhD Student
Genest, Genevieve PhD Student
Taylor, Nadine Administrative Assistant
Liu, Zhiyang MSc Student
Patel, Harshita MSc Student
Jiao, Zihan Undergraduate
Ste-Croix, Ashley PhD Student
Bektas, Irmak Undergraduate
Liu, Lewis Undergraduate

Latest Publications

  1. Dziarmaga, R., Ke, D., Sapir-Pichhadze, R., Cardinal, H., Phan, V., Piccirillo, C. A., Mazer, B. & Foster, B. J. (2021). Age- and sex-mediated differences in T lymphocyte populations of kidney transplant recipients. Pediatric transplantation, p. e14150.
  2. Huang, F., Gonçalves, C., Bartish, M., Rémy-Sarrazin, J., Issa, M. E., Cordeiro, B., Guo, Q., Emond, A., Attias, M., Yang, W., Plourde, D., Su, J., Gimeno, M. G., Zhan, Y., Galán, A., Rzymski, T., Mazan, M., Masiejczyk, M., Faber, J., Khoury, E., Benoit, A., Gagnon, N., Dankort, D., Journe, F., Ghanem, G. E., Krawczyk, C. M., Saragovi, H. U., Piccirillo, C. A., Sonenberg, N., Topisirovic, I., Rudd, C. E., Miller, W. H. & Del Rincón, S. V. (2021). Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. The Journal of clinical investigation, vol. 131.
  3. Grover, P., Goel, P. N., Piccirillo, C. A. & Greene, M. I. (2021). FOXP3 and Tip60 Structural Interactions Relevant to IPEX Development Lead to Potential Therapeutics to Increase FOXP3 Dependent Suppressor T Cell Functions. Frontiers in pediatrics, vol. 9, p. 607292.
  4. Ma, T., Song, X., Piccirillo, C. A., Deng, G. & Greene, M. I. (2021). A Structure-Guided Delineation of FOXP3 Regulation Mechanism in IPEX. Advances in experimental medicine and biology, vol. 1278, p. 33-46.
  5. Mehdi, A., Attias, M., Mahmood, N., Arakelian, A., Mihalcioiu, C., Piccirillo, C. A., Szyf, M. & Rabbani, S. A. (2020). Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma. Frontiers in oncology, vol. 10, p. 1361.
  6. Piccirillo, C. A. (2020). Transcriptional and translational control of Foxp3+ regulatory T cell functional adaptation to inflammation. Current opinion in immunology, vol. 67, p. 27-35.
  7. Park, J. H., Lee, K. H., Jeon, B., Ochs, H. D., Lee, J. S., Gee, H. Y., Seo, S., Geum, D., Piccirillo, C. A., Eisenhut, M., van der Vliet, H. J., Lee, J. M., Kronbichler, A., Ko, Y. & Shin, J. I. (2020). Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review. Autoimmunity reviews, vol. 19, p. 102526.
  8. Alvarez, F., Al-Aubodah, T.-A., Yang, Y. H. & Piccirillo, C. A. (2020). Mechanisms of TREG cell adaptation to inflammation. Journal of leukocyte biology, vol. 108, p. 559-571.
  9. Yang, Y. H., Istomine, R., Alvarez, F., Al-Aubodah, T.-A., Shi, X. Q., Takano, T., Thornton, A. M., Shevach, E. M., Zhang, J. & Piccirillo, C. A. (2020). Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. Cell reports, vol. 30, p. 1515-1529.e4.
  10. Forgetta, V., Manousaki, D., Istomine, R., Ross, S., Tessier, M.-C., Marchand, L., Li, M., Qu, H.-Q., Bradfield, J. P., Grant, S. F. A., Hakonarson, H., DCCT/EDIC Research Group, Paterson, A. D., Piccirillo, C., Polychronakos, C. & Richards, J. B. (2020). Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes. Diabetes, vol. 69, p. 784-795.
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See also

Card image
Moshe
Ben-Shoshan


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