Lab Information

Dr. Christos Tsoukas

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 50%
 Clinical: 50%
 Epidemiology: 0%
 Evaluation: 0%
 This email address is being protected from spambots. You need JavaScript enabled to view it.
 E03.5135 (modules G, H) /  #76258


Immune risk phenotype • inflammation • biomarkers • cardiovascular • immunopathology • cohort studies • T cell activation • primary immune deficiency

Research Interests

My research focuses on the interplay of HIV-associated chronic inflammation, immune activation, and accelerated aging. The risk of having medical conditions that are more frequently found in the elderly, such as heart disease, stroke, osteoporosis and dementia may relate to the premature aging of the immune system. I am currently conducting two large clinical studies of healthy Canadians and those with HIV to define the biological age of individuals as opposed to numerical age. Understanding immune parameters related to biological age may provide insight on why coronary artery disease may occur earlier in those with chronic inflammatory diseases.

Team Members

Name Position
Gilbert, Louise Research Assistant
Cutler, Debbie Administrative Assistant
Kabir, Aunonna MSc Student

Latest Publications

  1. Yero, A., Shi, T., Farnos, O., Routy, J.-P., Tremblay, C., Durand, M., Tsoukas, C., Costiniuk, C. T. & Jenabian, M.-A. (2021). Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection. EBioMedicine, vol. 71, p. 103570.
  2. Poloni, C., Szyf, M., Cheishvili, D. & Tsoukas, C. M. (2021). Are the healthy vulnerable? Cytomegalovirus seropositivity in healthy adults is associated with accelerated epigenetic age and immune-dysregulation. The Journal of infectious diseases.
  3. Alsulami, K., Bolastig, N., Dupuy, F. P., Mabanga, T., Gilbert, L., Kiani, Z., Routy, J.-P., Bruneau, J., Thomas, R., Tremblay, C., Tsoukas, C. M., Szabo, J., Côté, P., Trottier, B., LeBlanc, R., Rouleau, D., Bernard, N. F. & investigators in Montreal Primary HIV Infection cohort (2021). Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point. Journal of virology, p. JVI0041721.
  4. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2021). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, p. 1-7.
  5. Rothan, C., Yero, A., Shi, T., Farnos, O., Chartrand-Lefebvre, C., El-Far, M., Costiniuk, C. T., Tsoukas, C., Tremblay, C., Durand, M., Jenabian, M.-A. & Canadian HIV and Aging Cohort Study (2021). Antiretroviral therapy-treated HIV-infected adults with coronary artery disease are characterized by a distinctive regulatory T-cell signature. AIDS (London, England), vol. 35, p. 1003-1014.
  6. Poloni, C. & Tsoukas, C. (2020). Evaluating Immune Dysregulation in Patients With COVID-19 Requires a More Accurate Definition of the CD45RA+ T-cell Phenotype. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 71, p. 2306-2307.
  7. Matte, G., Shuster, J., Guevremont, C., Gold, P., Leong, F., Ngan, Z., Bonnici, A. & Tsoukas, C. (2020). Standardization and Updating of a Drug Allergy Testing Program: The McGill Experience and Impact on Pharmacy Activities. The Canadian journal of hospital pharmacy, vol. 73, p. 45-51.
  8. Moussa, Y., Sullivan, A., Matte, G., Goldstein, R. H., Baldini, G., Shuster, J. & Tsoukas, C. (2020). Impact of persistent β-lactam allergy documentation despite delabeling in the perioperative setting. The journal of allergy and clinical immunology. In practice, vol. 8, p. 411-412.
  9. Younger, J., Raboud, J., Szadkowski, L., Harrigan, R., Walmsley, S., Bayoumi, A. M., Klein, M. B., Cooper, C., Burchell, A. N., Loutfy, M., Hull, M., Wong, A., Thomas, R., Hogg, R., Montaner, J., Tsoukas, C., Antoniou, T. & Canadian Observational Cohort Collaboration (2019). Tenofovir and emtricitabine resistance among antiretroviral-naive patients in the Canadian Observational Cohort Collaboration: implications for PrEP. Antiviral therapy, vol. 24, p. 211-220.
  10. Costiniuk, C. T., Nitulescu, R., Saneei, Z., Wasef, N., Salahuddin, S., Wasef, D., Young, J., de Castro, C., Routy, J. P., Lebouché, B., Cox, J., Smith, B. M., Ambroise, S., Pexos, C., Patel, M., Szabo, J., Haraoui, L. P., de Pokomandy, A., Tsoukas, C., Falutz, J., LeBlanc, R., Giannakis, A., Frenette, C., Jenabian, M. A., Bourbeau, J. & Klein, M. B. (2019). Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross-sectional study. HIV medicine, vol. 20, p. 192-201.
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