Lab information

Dr. Martin Olivier

Senior Scientist

Research profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Leishmaniasis • malaria • exosome • innate inflammation • signaling

Research Interests

My research focuses on understanding how pathogens can evade the host immune response by manipulating the biochemical cascades involved in the regulation of phagocyte microbicidal functions. My pathogens of interest are protozoan parasites causing malaria, which causes up to two millions deaths annually, and leishmaniasis, which affects more than 250 million individuals worldwide. I have found that leishmania can tame the innate inflammatory response of the host, using its surface protease that can also be contained in microvesicules rapidly released within the host environment. For Malaria, my research revealed that a crystalline metabolic waste (HZ) of the parasite was responsible for a great number of inflammation-related pathologies encountered during this important infection. My lab's findings may lead to the development of new therapies against those infectious agents, which could be applied to others such as tuberculosis. They might also lead to the development of new diagnostic tools based on exo-biomarkers, and potentially to vaccine development.


Lab members

Name Role
Chin, Christopher Undergraduate
Martel, Caroline Research Assistant
Lira Filho, Alonso PhD Student
Dong, George PhD Student
Darbinian, Emma Undergraduate
Chan, Aretha MSc Student
Abusarah, Jamilah PhD Student
Carvalho Cabral, Priscilla PhD Student
Phan, Minh Phuong Intern
Heirwegh, Ellen Intern
Roy-Dorval, Audrey Undergraduate
Carstens-Kass, Jessica Intern
Desnoyers, Emilie Intern
Yu, Selena MSc Student
Daoudi, Mohamed Intern
Vialard, Fiorella MSc Student
Al-Emadi, Nada MSc Student
Carrera, Laura Intern

Latest publications

  1. Olivier, M., Minguez-Menendez, A. & Fernandez-Prada, C.
    (2019)
    .
    Leishmania Viannia guyanensis
    .
    Trends in parasitology
  2. Olivier, M. & Fernandez-Prada, C.
    (2019)
    .
    Leishmania and its exosomal pathway: a novel direction for vaccine development
    .
    Future microbiology
    ,
    vol
    .
    14
    ,
    p
    .
    559-561
    .
  3. Dong, G., Filho, A. L. & Olivier, M.
    (2019)
    .
    Modulation of Host-Pathogen Communication by Extracellular Vesicles (EVs) of the Protozoan Parasite Leishmania
    .
    Frontiers in cellular and infection microbiology
    ,
    vol
    .
    9
    ,
    p
    .
    100
    .
  4. Atayde, V. D., da Silva Lira Filho, A., Chaparro, V., Zimmermann, A., Martel, C., Jaramillo, M. & Olivier, M.
    (2019)
    .
    Publisher Correction: Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1
    .
    Nature microbiology
    ,
    vol
    .
    4
    ,
    p
    .
    724
    .
  5. Atayde, V. D., da Silva Lira Filho, A., Chaparro, V., Zimmermann, A., Martel, C., Jaramillo, M. & Olivier, M.
    (2019)
    .
    Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1
    .
    Nature microbiology
    ,
    vol
    .
    4
    ,
    p
    .
    714-723
    .
  6. Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J.-M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C., Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M. Á., Brigstock, D. R., Brisson, A., Broekman, M. L., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R., Caruso, S., Chamley, L. W., Chang, Y.-T., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A., Coyle, B., Crescitelli, R., Criado, M. F., D'Souza-Schorey, C., Das, S., Datta Chaudhuri, A., de Candia, P., De Santana, E. F., De Wever, O., Del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., El Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A.-G., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S.-I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E.-M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M.-S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-'t Hoen, E. N., Noren Hooten, N., O'Driscoll, L., O'Grady, T., O'Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Østergaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P.-R., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J.-Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K.
    (2018)
    .
    Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
    .
    Journal of extracellular vesicles
    ,
    vol
    .
    7
    ,
    p
    .
    1535750
    .
  7. Soares, R. P., Xander, P., Costa, A. O., Marcilla, A., Menezes-Neto, A., Del Portillo, H., Witwer, K., Wauben, M., Nolte-T Hoen, E., Olivier, M., Criado, M. F., da Silva, L. L. P., Abdel Baqui, M. M., Schenkman, S., Colli, W., Alves, M. J. M., Ferreira, K. S., Puccia, R., Nejsum, P., Riesbeck, K., Stensballe, A., Hansen, E. P., Jaular, L. M., Øvstebø, R., de la Canal, L., Bergese, P., Pereira-Chioccola, V., Pfaffl, M. W., Fritz, J., Gho, Y. S. & Torrecilhas, A. C.
    (2017)
    .
    Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication
    .
    Journal of extracellular vesicles
    ,
    vol
    .
    6
    ,
    p
    .
    1407213
    .
  8. Barrios-Correa, A. A., Estrada, J. A., Martel, C., Olivier, M., López-Santiago, R. & Contreras, I.
    (2018)
    .
    Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALB/c Mice
    .
    BioMed research international
    ,
    vol
    .
    2018
    ,
    p
    .
    3628121
    .
  9. Kiessling, S., Dubeau-Laramée, G., Ohm, H., Labrecque, N., Olivier, M. & Cermakian, N.
    (2017)
    .
    The circadian clock in immune cells controls the magnitude of Leishmania parasite infection
    .
    Scientific reports
    ,
    vol
    .
    7
    ,
    p
    .
    10892
    .
  10. Cinti, A., Le Sage, V., Milev, M. P., Valiente-Echeverría, F., Crossie, C., Miron, M.-J., Panté, N., Olivier, M. & Mouland, A. J.
    (2017)
    .
    HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
    .
    Scientific reports
    ,
    vol
    .
    7
    ,
    p
    .
    5515
    .
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Latest IDIGH Publications

  1. Roussel, L., Landekic, M., Golizeh, M., Gavino, C., Zhong, M.-C., Chen, J., Faubert, D., Blanchet-Cohen, A., Dansereau, L., Parent, M.-A., Marin, S., Luo, J., Le, C., Ford, B. R., Langelier, M., King, I. L., Divangahi, M., Foulkes, W. D., Veillette, A. & Vinh, D. C.
    (2019)
    .
    [Loss of human ICOSLG results in combined immunodeficiency]
    .
    Medecine sciences : M/S
    ,
    vol
    .
    35
    ,
    p
    .
    625-628
    .
  2. Cheng, M. P., Stenstrom, R., Paquette, K., Stabler, S. N., Akhter, M., Davidson, A. C., Gavric, M., Lawandi, A., Jinah, R., Saeed, Z., Demir, K., Huang, K., Mahpour, A., Shamatutu, C., Caya, C., Troquet, J.-M., Clark, G., Yansouni, C. P., Sweet, D. & FABLED Investigators.
    (2019)
    .
    Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
    .
    Annals of internal medicine
  3. Pearce, M. E., Jongbloed, K., Demerais, L., MacDonald, H., Christian, W. M., Sharma, R., Pick, N., Yoshida, E. M., Spittal, P. M. & Klein, M. B.
    (2019)
    .
    "Another thing to live for": Supporting HCV treatment and cure among Indigenous people impacted by substance use in Canadian cities
    .
    The International journal on drug policy
    ,
    vol
    .
    74
    ,
    p
    .
    52-61
    .
  4. Eiwegger, T., Anagnostou, K., Arasi, S., Bégin, P., Ben-Shoshan, M., Beyer, K., Blumchen, K., Brough, H., Caubet, J.-C., Chan, E. S., Chinthrajah, S., Davis, C. M., Roches, A. D., Du Toit, G., Elizur, A., Galli, S. J., Håland, G., Hoffmann-Sommergruber, K., Kim, H., Leung, D. Y. M., Muraro, A., Nurmatov, U. B., Pajno, G. B., Sindher, S., Szepfalusi, Z., Torres, M. J., Upton, J., Worm, M. & Nadeau, K.
    (2019)
    .
    ICER report for peanut OIT comes up short
    .
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  5. Kiani, Z., Dupuy, F. P., Bruneau, J., Lebouché, B., Retière, C., Geraghty, D. E. & Bernard, N. F.
    (2019)
    .
    The Education of NK Cells Determines Their Responsiveness to Autologous HIV-Infected CD4 T Cells
    .
    Journal of virology
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