Lab information

Dr. John Di Battista

Senior Scientist

Research profile

 Fundamental: 75%
 Clinical: 25%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Signaling • genetics • proteomics • G protein-coupled receptors (GPCRs) • inflammation

Research Interests

My research focuses on G-protein coupled receptor signaling pathways regulating the inflammatory response.


Lab members

Name Role

Latest publications

  1. Zhao, C., Amiable, N., Laflamme, M., Marsolais, D., Di Battista, J. A., Fernandes, M. J. & Bourgoin, S. G.
    (2019)
    .
    Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
    .
    Biochemical pharmacology
    ,
    vol
    .
    165
    ,
    p
    .
    249-262
    .
  2. Gerarduzzi, C. & Di Battista, J. A.
    (2017)
    .
    Myofibroblast repair mechanisms post-inflammatory response: a fibrotic perspective
    .
    Inflammation research : official journal of the European Histamine Research Society ... [et al.]
    ,
    vol
    .
    66
    ,
    p
    .
    451-465
    .
  3. Gerarduzzi, C., He, Q., Zhai, B., Antoniou, J. & Di Battista, J. A.
    (2017)
    .
    Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration
    .
    Journal of cellular physiology
    ,
    vol
    .
    232
    ,
    p
    .
    202-15
    .
  4. Zhao, C., Moreno-Nieves, U., Di Battista, J. A., Fernandes, M. J., Touaibia, M. & Bourgoin, S. G.
    (2015)
    .
    Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts
    .
    Mediators of inflammation
    ,
    vol
    .
    2015
    ,
    p
    .
    436525
    .
  5. Gerarduzzi, C., He, Q., Antoniou, J. & Di Battista, J. A.
    (2014)
    .
    Quantitative phosphoproteomic analysis of signaling downstream of the prostaglandin e2/g-protein coupled receptor in human synovial fibroblasts: potential antifibrotic networks
    .
    Journal of proteome research
    ,
    vol
    .
    13
    ,
    p
    .
    5262-80
    .
  6. Di Battista, J. A., Shebaby, W., Kizilay, O., Hamade, E., Abou Merhi, R., Mebarek, S., Abdallah, D., Badran, B., Saad, F., K Abdalla, E. & Faour, W. H.
    (2014)
    .
    Proliferation and differentiation of human adipose-derived mesenchymal stem cells (ASCs) into osteoblastic lineage are passage dependent
    .
    Inflammation research : official journal of the European Histamine Research Society ... [et al.]
    ,
    vol
    .
    63
    ,
    p
    .
    907-17
    .
  7. Gerarduzzi, C., He, Q., Antoniou, J. & Di Battista, J. A.
    (2014)
    .
    Prostaglandin E(2)-dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2
    .
    Journal of cellular biochemistry
    ,
    vol
    .
    115
    ,
    p
    .
    1516-27
    .
  8. Mancini, A. D. & Di Battista, J. A.
    (2011)
    .
    The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis
    .
    Inflammation research : official journal of the European Histamine Research Society ... [et al.]
    ,
    vol
    .
    60
    ,
    p
    .
    1083-92
    .
  9. Zhai, B., Yang, H., Mancini, A., He, Q., Antoniou, J. & Di Battista, J. A.
    (2010)
    .
    Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway
    .
    The Journal of biological chemistry
    ,
    vol
    .
    285
    ,
    p
    .
    23568-80
    .
  10. Cybulsky, A. V., Takano, T., Guillemette, J., Papillon, J., Volpini, R. A. & Di Battista, J. A.
    (2009)
    .
    The Ste20-like kinase SLK promotes p53 transactivation and apoptosis
    .
    American journal of physiology. Renal physiology
    ,
    vol
    .
    297
    ,
    p
    .
    F971-80
    .
More on PubMed

IDIGH Calendar

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Latest IDIGH Publications

  1. Roussel, L., Landekic, M., Golizeh, M., Gavino, C., Zhong, M.-C., Chen, J., Faubert, D., Blanchet-Cohen, A., Dansereau, L., Parent, M.-A., Marin, S., Luo, J., Le, C., Ford, B. R., Langelier, M., King, I. L., Divangahi, M., Foulkes, W. D., Veillette, A. & Vinh, D. C.
    (2019)
    .
    [Loss of human ICOSLG results in combined immunodeficiency]
    .
    Medecine sciences : M/S
    ,
    vol
    .
    35
    ,
    p
    .
    625-628
    .
  2. Cheng, M. P., Stenstrom, R., Paquette, K., Stabler, S. N., Akhter, M., Davidson, A. C., Gavric, M., Lawandi, A., Jinah, R., Saeed, Z., Demir, K., Huang, K., Mahpour, A., Shamatutu, C., Caya, C., Troquet, J.-M., Clark, G., Yansouni, C. P., Sweet, D. & FABLED Investigators.
    (2019)
    .
    Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
    .
    Annals of internal medicine
  3. Pearce, M. E., Jongbloed, K., Demerais, L., MacDonald, H., Christian, W. M., Sharma, R., Pick, N., Yoshida, E. M., Spittal, P. M. & Klein, M. B.
    (2019)
    .
    "Another thing to live for": Supporting HCV treatment and cure among Indigenous people impacted by substance use in Canadian cities
    .
    The International journal on drug policy
    ,
    vol
    .
    74
    ,
    p
    .
    52-61
    .
  4. Eiwegger, T., Anagnostou, K., Arasi, S., Bégin, P., Ben-Shoshan, M., Beyer, K., Blumchen, K., Brough, H., Caubet, J.-C., Chan, E. S., Chinthrajah, S., Davis, C. M., Roches, A. D., Du Toit, G., Elizur, A., Galli, S. J., Håland, G., Hoffmann-Sommergruber, K., Kim, H., Leung, D. Y. M., Muraro, A., Nurmatov, U. B., Pajno, G. B., Sindher, S., Szepfalusi, Z., Torres, M. J., Upton, J., Worm, M. & Nadeau, K.
    (2019)
    .
    ICER report for peanut OIT comes up short
    .
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  5. Kiani, Z., Dupuy, F. P., Bruneau, J., Lebouché, B., Retière, C., Geraghty, D. E. & Bernard, N. F.
    (2019)
    .
    The Education of NK Cells Determines Their Responsiveness to Autologous HIV-Infected CD4 T Cells
    .
    Journal of virology
More publications