Hideki Ueno, MD, PhD
Department of Microbiology
Global Health and Emerging Pathogens Institute
Icahn School of Medicine at Mount Sinai
Department of Immunology
Graduate School of Medicine, Kyoto University
Institute for the Advanced Study of Human Biology, Kyoto University
Hideki Ueno, M.D, Ph.D. is a Professor at the Global Health and Emerging Pathogens Institute in the Department of Microbiology. With more than 15 years experience in human immunology, Dr. Ueno’s research focuses on the human adaptive immune system – the major immunological protection mechanism in charge of generation and maintenance of antigen-specific immune responses. The major research topic in the past decade in the Dr. Ueno Laboratory has been the biology of human T follicular helper (Tfh) cells, a CD4+ T cell subset fundamental for the generation of antibody responses. His laboratory has identified functionally distinct subsets within blood circulating Tfh cells in humans. This seminal work has been cited more than 600 times. This work has led to their identification of cTfh1 cells in charge of antibody responses following seasonal influenza vaccination. The Dr. Ueno laboratory also identified multiple key factors and pathways promoting the differentiation of human Tfh cells, including the IL-12-STAT4 axis.