Hideki Ueno, MD, PhD


Professor
Department of Microbiology
Global Health and Emerging Pathogens Institute
Icahn School of Medicine at Mount Sinai

Professor
Department of Immunology
Graduate School of Medicine, Kyoto University

Primary Investigator
Institute for the Advanced Study of Human Biology, Kyoto University

http://labs.icahn.mssm.edu/uenolab/dr-ueno/


Hideki Ueno, M.D, Ph.D. is a Professor at the Global Health and Emerging Pathogens Institute in the Department of Microbiology. With more than 15 years experience in human immunology, Dr. Ueno’s research focuses on the human adaptive immune system –  the major immunological protection mechanism in charge of generation and maintenance of antigen-specific immune responses. The major research topic in the past decade in the Dr. Ueno Laboratory has been the biology of human T follicular helper (Tfh) cells, a CD4+ T cell subset fundamental for the generation of antibody responses. His laboratory has identified functionally distinct subsets within blood circulating Tfh cells in humans. This seminal work has been cited more than 600 times. This work has led to their identification of cTfh1 cells in charge of antibody responses following seasonal influenza vaccination. The Dr. Ueno laboratory also identified multiple key factors and pathways promoting the differentiation of human Tfh cells, including the IL-12-STAT4 axis.

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Latest IDIGH Publications

  1. Xu, G., van Bruggen, R., Gualtieri, C. O., Moradin, N., Fois, A., Vallerand, D., De Sa Tavares Russo, M., Bassenden, A., Lu, W., Tam, M., Lesage, S., Girouard, H., Avizonis, D. Z., Deblois, G., Prchal, J. T., Stevenson, M., Berghuis, A., Muir, T., Rabinowitz, J., Vidal, S. M., Fodil, N. & Gros, P.
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    Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia
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    Cell reports
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    32
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    108170
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  2. Isnard, S., Lin, J., Fombuena, B., Ouyang, J., Varin, T. V., Richard, C., Marette, A., Ramendra, R., Planas, D., Raymond Marchand, L., Messaoudene, M., Van der Ley, C. P., Kema, I. P., Sohail Ahmed, D., Zhang, Y., Finkelman, M., Routy, B., Angel, J., Ancuta, P. & Routy, J.-P.
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    Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota
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    Open forum infectious diseases
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    7
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    ofaa338
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  3. Lopez-Olivo, M. A., Colmegna, I., Karpes, A. R., Qi, S. R., Zamora, N. V., Sharma, R., Pratt, G. & Suarez-Almazor, M. E.
    (2020)
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    Systematic Review of Recommendations on the Use of Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis and Cancer: Reply to a Comment
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    Arthritis care & research
  4. Zhao, N., Smargiassi, A., Colmegna, I., Hudson, M., Fritzler, M. & Bernatsky, S.
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    Sunlight exposure, sun-protective behaviour, and anti-citrullinated protein antibody positivity: A general population-based study in Quebec, Canada
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    Arthritis care & research
  5. D'Souza, R., Ashraf, R., Rowe, H., Zipursky, J., Clarfield, L., Maxwell, C., Arzola, C., Lapinsky, S., Paquette, K., Murthy, S., Cheng, M. P. & Malhamé, I.
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    Pregnancy and COVID-19: Pharmacologic Considerations
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    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
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